THE EFFECTS OF MUSCIMOL INJECTION INTO BASOLATERAL AMYGDALA ON SPATIAL MEMORY PROCESSING IN PLACE AVOIDANCE LEARNING TASK

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RASHIDIPOUR A.; VAFAEE A.A.

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Journal: Koomesh Year:2001 | Volume:2 | Issue:2 Page(s): 73-81

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Title

THE EFFECTS OF MUSCIMOL INJECTION INTO BASOLATERAL AMYGDALA ON SPATIAL MEMORY PROCESSING IN PLACE AVOIDANCE LEARNING TASK

Author(s)

RASHIDIPOUR A. | VAFAEE A.A. | Issue Writer Certificate

Keywords

BASOLATERAL AMYGDALAQ4

SPATIAL MEMORYQ4

GABAERGIC AGONIST (MUSCIMOL)Q4

Abstract

Introduction: The present experiment examined the effect of pre and posttraining and before of retreival test injections of muscimol, a GABA agonist, into BASOLATERAL AMYGDALA (BLA) on retention of SPATIAL MEMORY in place avoidance learning task. Materials and Methods: Male Long-Evans strain rats were surgically implanted bilaterally with cannulae aimed at the BLA and were trained to avoid a 60 degree segment of the arena entering which was punished by mild footshock. Place avoidance training occurred in a single 30-min session and the avoidance memory was assessed during a 30-min extinction trial 24 h later. The time to the first entry and the number of entrances into the punished sector during extinction were used to measure the place avoidance memory. Muscimol (0.5µg/0.6µl, per side) as a GABAergic agonist were injected bilaterally and unilaterally into BLA immediately after training and before retreival test. Retention test was done one day later. Results: Results indicated that infusion of muscimol before and immediately after training into BLA significantly impaired retention performance. Infusion of muscimol before retrieval test into BLA bilaterally and unilaterally only right amygdala not left significantly impaired retention performance. Conclusion: The above results show that GABAergic receptor plays an important role in acquisition and consolidation of SPATIAL MEMORY in place avoidance learning. Also this result show that GABAergic system play an important role on retreival of SPATIAL MEMORY in BLA of the amygdala and this role is very important in right BLA.

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APA: Copy

RASHIDIPOUR, A., & VAFAEE, A.A.. (2001). THE EFFECTS OF MUSCIMOL INJECTION INTO BASOLATERAL AMYGDALA ON SPATIAL MEMORY PROCESSING IN PLACE AVOIDANCE LEARNING TASK. KOOMESH, 2(2), 73-81. SID. https://sid.ir/paper/37544/en

Vancouver: Copy

RASHIDIPOUR A., VAFAEE A.A.. THE EFFECTS OF MUSCIMOL INJECTION INTO BASOLATERAL AMYGDALA ON SPATIAL MEMORY PROCESSING IN PLACE AVOIDANCE LEARNING TASK. KOOMESH[Internet]. 2001;2(2):73-81. Available from: https://sid.ir/paper/37544/en

IEEE: Copy

A. RASHIDIPOUR, and A.A. VAFAEE, “THE EFFECTS OF MUSCIMOL INJECTION INTO BASOLATERAL AMYGDALA ON SPATIAL MEMORY PROCESSING IN PLACE AVOIDANCE LEARNING TASK,” KOOMESH, vol. 2, no. 2, pp. 73–81, 2001, [Online]. Available: https://sid.ir/paper/37544/en

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