EFFECTS OF PAROMOMYCIN AND GENTAMICINE SULPHATE ON PROMASTIGOTES OF LEISHMANIA MAJOR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEJAZI H.; TOLOUEI S.; ASILIAN A.; SHATALEBI M.; MOSTAGHIM M.; SADEGHIAN G.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2004 | Volume:8 | Issue:29 Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,234

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF PAROMOMYCIN AND GENTAMICINE SULPHATE ON PROMASTIGOTES OF LEISHMANIA MAJOR

Author(s)

Keywords

PAROMOMYCINQ4

GENTAMICINEQ4

LEISHMANIAQ4

CLONING.Q4

Abstract

Background: With respect to the prevalence of leishmaniosis in our country and the problems occurred in the therapeutic approaches and also with respect to the previous successful reports of PAROMOMYCIN efficacy in this regard, the present study was conducted to determine the effects of PAROMOMYCIN and GENTAMICINE sulphate on promastigotes of LEISHMANIA major. Materials and methods: It was an experimental study. The base of films composed of ethyl cellulose and HPMC (hydroxyl propyl methyl cellulose) containing PAROMOMYCIN 15% and GENTAMICINE 0.5%. To determine the rate and duration release from the films and its killing effects on LEISHMANIA promastigotes, a CLONING.system of parasite was established by using a set of modified NNN medium without liquid layer. The medium plates were divided in 3 groups, the media contain of drug films, placebo films, and media containing no film. Results: results showed no colonies of LEISHMANIA in a 30mm radius envelop the drug films. On the other hand, grown colonies of LEISHMANIA promastigotes were found in placebo and control plates. Frequency of dead parasites were 98% and 5% in the placebo-control plates and drug plates, respectively (p<0.000). Conclusion: PAROMOMYCIN and GENTAMICINE drug films have good potential of drug releasing and suitable killing effects in vitro condition. It is suggested that the therapeutic effect of this new form of drug be achieved in human models.

Cites

No record.

References

No record.

Cite

APA: Copy

HEJAZI, H., TOLOUEI, S., ASILIAN, A., SHATALEBI, M., MOSTAGHIM, M., & SADEGHIAN, G.. (2004). EFFECTS OF PAROMOMYCIN AND GENTAMICINE SULPHATE ON PROMASTIGOTES OF LEISHMANIA MAJOR. FEYZ, 8(29), 0-0. SID. https://sid.ir/paper/376505/en

Vancouver: Copy

HEJAZI H., TOLOUEI S., ASILIAN A., SHATALEBI M., MOSTAGHIM M., SADEGHIAN G.. EFFECTS OF PAROMOMYCIN AND GENTAMICINE SULPHATE ON PROMASTIGOTES OF LEISHMANIA MAJOR. FEYZ[Internet]. 2004;8(29):0-0. Available from: https://sid.ir/paper/376505/en

IEEE: Copy

H. HEJAZI, S. TOLOUEI, A. ASILIAN, M. SHATALEBI, M. MOSTAGHIM, and G. SADEGHIAN, “EFFECTS OF PAROMOMYCIN AND GENTAMICINE SULPHATE ON PROMASTIGOTES OF LEISHMANIA MAJOR,” FEYZ, vol. 8, no. 29, pp. 0–0, 2004, [Online]. Available: https://sid.ir/paper/376505/en

Related Journal Papers