EFFECTS OF EXHAUSTIVE AEROBIC ACTIVITY ON MMPS ACTIVITY IN ATHLETES AND NON-ATHLETES

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AMIR SASAN R.; MIRSHAFIEI A.; GAEINI A.A.; RAVASI A.A.; SAADAT F.; BIOURANI H.

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Journal: OLYMPIC Year:2008 | Volume:15 | Issue:4 (SERIAL 40) Page(s): 59-71

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Title

EFFECTS OF EXHAUSTIVE AEROBIC ACTIVITY ON MMPS ACTIVITY IN ATHLETES AND NON-ATHLETES

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Keywords

MMP2 AND MMP9Q3

EXHAUSTIVE AEROBIC ACTIVITYQ3

Abstract

Matrix metaloproteases (MMPS) belong to a main group of proteases which have roll in extracellular matrix degradation. Their activities such as wounds healing and angiogenesis are very important in physiological conditions, but they are transient and under the control of endogenous blockers. In pathological processes such as in case of disease and after physical and mechanical stresses, expression and activity of these proteolysic increases, due to preinflammatory cytokines secretion and lead to collagen and gelatin degradation and disruption of micro anatomical structure of tissues. In these circumstances, along with the time, this can lead to worse inflammation and displaying many of disease such as cardiac injuries and damage to blood vessels epithelium, forward cancer cells development and osteoporosis. In should be noted that, because of the novelty this topic about (MMPS) and their responses to physical activities, there is not any consensus between researchers. The aim of this research was to investigate effects of one exhaustive endurance exercise session on MMP2 and MMP9 activities (the most complex and the most abundant enzymes) in male well trained and untrained peoples. So 11 elite male endurance runners which have trained at least for 5 years in clubs or national team camps (age: 22.27±3.87; Vo2max: 60.68±6.19) and 10 untrained male subject (age: 23±4.04; Vo2max: 37.90±5.90) participated voluntarily in this research. Blood samples were collected from two groups in three phase which they include: basal levels (20 minutes before exercise), 20 and 24 hour after end of exercise. Then the variables were measured by means of gelatin zymography technique and collected data were analyzed with ANOVA and post-hoc and independent T student tests. The result showed that blood MMP2 and MMP9 levels increased following of one EXHAUSTIVE AEROBIC ACTIVITY session (P<0.001). It should be noted that despite of significant decrease of MMP2 and MMP9 levels after 24 hour (P<0.001), but their levels were higher than basal levels (P<0.001). In all phases of measurements, changes of MMP2 and MMP9 activities in non-athletes were similar to those in athletes but none of these changes were significant. Moreover, athletes MMP2 and MMP9 activities in pre-exercise, 20 and 24 hour after exercise were significantly higher than non-athletes (P<0.001). Conclusion: With increasing MMPS activities inflammatory responses to physical and mechanical stimuli (one session of exhaustive exercise) has been started in both of subjects (well trained and untrained) which continued up to 34 hours after exercise. In seems that, the rate of mentioned inflammatory indices responses is dependent on the duration and intensity of the exercise.

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APA: Copy

AMIR SASAN, R., MIRSHAFIEI, A., GAEINI, A.A., RAVASI, A.A., SAADAT, F., & BIOURANI, H.. (2008). EFFECTS OF EXHAUSTIVE AEROBIC ACTIVITY ON MMP_S ACTIVITY IN ATHLETES AND NON-ATHLETES. OLYMPIC, 15(4 (SERIAL 40)), 59-71. SID. https://sid.ir/paper/37765/en

Vancouver: Copy

AMIR SASAN R., MIRSHAFIEI A., GAEINI A.A., RAVASI A.A., SAADAT F., BIOURANI H.. EFFECTS OF EXHAUSTIVE AEROBIC ACTIVITY ON MMP_S ACTIVITY IN ATHLETES AND NON-ATHLETES. OLYMPIC[Internet]. 2008;15(4 (SERIAL 40)):59-71. Available from: https://sid.ir/paper/37765/en

IEEE: Copy

R. AMIR SASAN, A. MIRSHAFIEI, A.A. GAEINI, A.A. RAVASI, F. SAADAT, and H. BIOURANI, “EFFECTS OF EXHAUSTIVE AEROBIC ACTIVITY ON MMP_S ACTIVITY IN ATHLETES AND NON-ATHLETES,” OLYMPIC, vol. 15, no. 4 (SERIAL 40), pp. 59–71, 2008, [Online]. Available: https://sid.ir/paper/37765/en

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