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Information Journal Paper

Title

Evaluation of the Effects of Ascorbic Acid on Doxorubicin-Induced Hepatotoxicity in Mice

Pages

  341-347

Abstract

 BACKGROUND: Doxorubicin is one of the most widely used antiCancer chemotherapeutic agents in small animal practice. The use of Doxorubicin can cause cardiotoxicity, Hepatotoxicity, neurotoxicity, and nephrotoxicity. OBJECTIVES: This study was carried out to evaluate the effects of Ascorbic acid on Doxorubicin Hepatotoxicity in Mice. METHODS: Twenty-four Balb/c Mice were randomly divided into four groups. Group one received normal saline, group two received 100 mg/kg Ascorbic acid, group three received 8 mg/kg Doxorubicin and group four received Ascorbic acid and Doxorubicin intraperitoneally, with the same doses of groups 2 and 3. Twenty-one days after injection, the Mice were euthanized. The activities of ALP, ALT, AST enzymes and total bilirubin levels in the serum samples were measured. Liver samples were evaluated histopathologically. RESULTS: The activities of ALP, ALT, AST, and total bilirubin levels and histopathologic scores of Hepatotoxicity were significantly lower in the group that received Ascorbic acid + Doxorubicin in comparison to those of the Doxorubicin group. CONCLUSIONS: Ascorbic acid may be useful in the prevention of Doxorubicin Hepatotoxicity in Mice. Further studies are recommended for evaluation of the use of Ascorbic acid in small animals.

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    APA: Copy

    Hatamkhani, Ali, Shirani, Dariush, Rassouli, Ali, BOKAEI, SAEED, & DEZFOULIAN, OMID. (2020). Evaluation of the Effects of Ascorbic Acid on Doxorubicin-Induced Hepatotoxicity in Mice. JOURNAL OF VETERINARY RESEARCH, 75(3 ), 341-347. SID. https://sid.ir/paper/378047/en

    Vancouver: Copy

    Hatamkhani Ali, Shirani Dariush, Rassouli Ali, BOKAEI SAEED, DEZFOULIAN OMID. Evaluation of the Effects of Ascorbic Acid on Doxorubicin-Induced Hepatotoxicity in Mice. JOURNAL OF VETERINARY RESEARCH[Internet]. 2020;75(3 ):341-347. Available from: https://sid.ir/paper/378047/en

    IEEE: Copy

    Ali Hatamkhani, Dariush Shirani, Ali Rassouli, SAEED BOKAEI, and OMID DEZFOULIAN, “Evaluation of the Effects of Ascorbic Acid on Doxorubicin-Induced Hepatotoxicity in Mice,” JOURNAL OF VETERINARY RESEARCH, vol. 75, no. 3 , pp. 341–347, 2020, [Online]. Available: https://sid.ir/paper/378047/en

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