The treatment effect of probiotic Bacillus coagulans on male Parkinson's rats

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Mirzanaeni Simindokht; PAKPOUR BAHAREH; Navabian Majid

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Journal: JOURNAL OF APPLIED MICROBIOLOGY IN FOOD INDUSTRY Year:2019 | Volume:5 | Issue:3 Page(s): 17-30

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Title

The treatment effect of probiotic Bacillus coagulans on male Parkinson's rats

Author(s)

Mirzanaeni Simindokht | PAKPOUR BAHAREH | Navabian Majid | Issue Writer Certificate

Keywords

Bacillus coagulanceQ1

Parkinson's diseaseQ1

probioticsQ2

treatment and ratsQ1

Abstract

Parkinson's disease after Alzheimer's is the most common neurodegenerative disease. It is the second most commonly reported neurodegenerative disorder. To create an animal model of Parkinson's disease, the black dense component of rats in 6-hydroxy dopamine (6-OHDA) was unilaterally destroyed in a stereotactic device. After 3 weeks, in order to evaluate the degradation rate, intra-peritoneal rats were given apomorphine they received. The number of spins was counted for one hour after the injection. These rotations were the main parameter for diagnosis of Parkinson's disease in rats. After a month, they received probiotic treatment for one month. After this, once again, the apomorphine test was performed and the result was compared with the previous series. In the Parkinson's group who received probiotics, the number of spins from apomorphine injected significantly decreased compared with the Parkinson's group receiving probiotics (p≤ 0. 001). In addition, Parkinson's group showed more rotation than the sham group. The results showed that, on the one hand, neurotoxin-6-hydroxy dopamine can cause Parkinson’ s formation in rats, with dopamine agonist injections rotate. probiotics, on the other hand, can reduce the number of rotations and play a role in improving it. One of the main causes of Parkinson's disease is the imbalance between free radicals and antioxidants. The use of probiotics increases the antioxidants and reduces free radicals. Many studies have shown the role of dopamine receptor agitation in neurological disorders such as Parkinson's. According to the results of this study, the probabilistic probability of Bacillus coagulance with increasing dopamine expression led to improvement of neurological disorders and treatment of Parkinson's disease in rats. The black body is the main source of dopamine secretion that plays an effective role in controlling voluntary movements and coordination in musculoskeletal conditions. Regarding the fact that in this study, 6 hydroxy-dopamine degrading regions of the brain reduced the concentration of dopamine and created Parkinson's. probiotics may improve the disease through the concentration of dopamine in other centers of the central nervous system.

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APA: Copy

Mirzanaeni, Simindokht, PAKPOUR, BAHAREH, & Navabian, Majid. (2019). The treatment effect of probiotic Bacillus coagulans on male Parkinson's rats. JOURNAL OF APPLIED MICROBIOLOGY IN FOOD INDUSTRY, 5(3 ), 17-30. SID. https://sid.ir/paper/378162/en

Vancouver: Copy

Mirzanaeni Simindokht, PAKPOUR BAHAREH, Navabian Majid. The treatment effect of probiotic Bacillus coagulans on male Parkinson's rats. JOURNAL OF APPLIED MICROBIOLOGY IN FOOD INDUSTRY[Internet]. 2019;5(3 ):17-30. Available from: https://sid.ir/paper/378162/en

IEEE: Copy

Simindokht Mirzanaeni, BAHAREH PAKPOUR, and Majid Navabian, “The treatment effect of probiotic Bacillus coagulans on male Parkinson's rats,” JOURNAL OF APPLIED MICROBIOLOGY IN FOOD INDUSTRY, vol. 5, no. 3 , pp. 17–30, 2019, [Online]. Available: https://sid.ir/paper/378162/en

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