EFFECT OF AMOUNT AND POLYMER TYPE ON SOLID STATE PHYSICAL STABILITY AND DISSOLUTION OF DILTIAZEM SUSTAINED RELEASE TABLETS

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ENAYATI FARD REZA; SAEEDI MAJID; AKBARI JAFAR; SHAFIEE VAJIHEH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:21 | Issue:SUPPLEMENT 1 Page(s): 216-226

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Title

EFFECT OF AMOUNT AND POLYMER TYPE ON SOLID STATE PHYSICAL STABILITY AND DISSOLUTION OF DILTIAZEM SUSTAINED RELEASE TABLETS

Author(s)

ENAYATI FARD REZA | SAEEDI MAJID | AKBARI JAFAR | SHAFIEE VAJIHEH | Issue Writer Certificate

Keywords

DILTIAZEMQ2

STABILITYQ2

RELEASEQ2

Abstract

Background and purpose: Factors such as formulation components and storage conditions can affect the dissolution STABILITY of a drug product. The physicochemical properties of pharmaceutical solids are dependent on the presence of moisture and temperature. The change in the physicochemical properties can produce variation in the drug RELEASE, resulting in changes in the bioavailability. In order to overcome such variation, it's necessary to determine the storage conditions required to obtain a predictable drug RELEASE.Materials and methods: Tablet formulations containing DILTIAZEM, ethylcellulose, HPMC K4M and magnesium stearate were prepared by the direct compression method. The objective of the study was to assess the STABILITY of these formulations after subjecting them to different condition of temperature and humidity (25, 60% RH and 40, 75% RH). The samples were analyzed for thermal and dissolution changes with time for a period of six months. Differential scanning calorimetry (DSC) were used for thermal studies.Results: The RELEASE profiles for matrices prepared from different amount of HPMC K4M and ethyl cellulose showed that drug RELEASE decreased with increasing of the amount of HPMC K4M, and RELEASE of DILTIAZEM increased with increasing of the amount of ethyl cellulose. The DSC thermo grams of different formulations of DILTIAZEM showed a peak of DILTIAZEM in 210 degree of centigrade.Conclusion: Stabilty studies demonstrated no interaction between tablet components of different formulations and reproducible drug RELEASE patterns for matrix tablets stored at 25oC, 60% RH and 40oC, 75% RH up to 6 months.

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APA: Copy

ENAYATI FARD, REZA, SAEEDI, MAJID, AKBARI, JAFAR, & SHAFIEE, VAJIHEH. (2012). EFFECT OF AMOUNT AND POLYMER TYPE ON SOLID STATE PHYSICAL STABILITY AND DISSOLUTION OF DILTIAZEM SUSTAINED RELEASE TABLETS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(SUPPLEMENT 1), 216-226. SID. https://sid.ir/paper/379055/en

Vancouver: Copy

ENAYATI FARD REZA, SAEEDI MAJID, AKBARI JAFAR, SHAFIEE VAJIHEH. EFFECT OF AMOUNT AND POLYMER TYPE ON SOLID STATE PHYSICAL STABILITY AND DISSOLUTION OF DILTIAZEM SUSTAINED RELEASE TABLETS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;21(SUPPLEMENT 1):216-226. Available from: https://sid.ir/paper/379055/en

IEEE: Copy

REZA ENAYATI FARD, MAJID SAEEDI, JAFAR AKBARI, and VAJIHEH SHAFIEE, “EFFECT OF AMOUNT AND POLYMER TYPE ON SOLID STATE PHYSICAL STABILITY AND DISSOLUTION OF DILTIAZEM SUSTAINED RELEASE TABLETS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. SUPPLEMENT 1, pp. 216–226, 2012, [Online]. Available: https://sid.ir/paper/379055/en

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