VITAMIN E PLASMA CONCENTRATION IN OSTEOPOROTIC PATIENTS

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HAJI MAHMOUDI MANAN; SADEGHI N.; MIRABZADEH M.; HAJI BABAEI MOLOUK; JANAT B.; JAMSHIDI A.R.

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Journal: Tehran University Medical Journal Year:2007 | Volume:65 | Issue:1 Page(s): 79-85

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Title

VITAMIN E PLASMA CONCENTRATION IN OSTEOPOROTIC PATIENTS

Author(s)

Keywords

OSTEOPOROSISQ3

VITAMIN EQ3

ANTIOXIDANTSQ3

Abstract

Background: The cause of OSTEOPOROSIS is multifactorial and many dietary factors are important in the prevention of this disease. ANTIOXIDANTS as free radical scavengers may influence OSTEOPOROSIS by reducing the effects of oxidative stress that may be associated with bone loss. VITAMIN E is an important antioxidant that protects polyunsaturated fatty acids (PUFA) in cell membranes from oxidation. There are only two studies regarding VITAMIN E plasma levels in subjects suffering from OSTEOPOROSIS. The purpose of this study was to investigate the association between plasma VITAMIN E levels and bone mineral density (BMD) in Iranian patients.Methods: Subjects were consecutively recruited between May and September 2005 from among a total of approximately 1000 people referred for instrumental screening for OSTEOPOROSIS to the Jami Clinic in Tehran. Inclusion criteria for the study group were: a femoral neck T-score of -1 or less, osteopenia, severe osteopenia and OSTEOPOROSIS. A total of 137 subjects were enrolled. According to their femoral and spinal BMD scores, 54 persons were selected as a control group. The control group consisted of subjects with a femoral neck T-score and spine T-score of -1 or more. In selecting the case group, only the femoral BMD score was used. Plasma VITAMIN E was measured, after extraction with methanol, by HPLC with UV detection at 280 nm. Methanol, deionized water and butanol (90:4:6) was used as a mobile phase with a C8 column. The flow rate was 1.0 ml. min-1 and the acetate ester of VITAMIN E was used as an internal standard.Results: The results show no significant difference in plasma VITAMIN E between the control and case groups, however linear regression analysis does reveal a significant difference between the T-score and plasma VITAMIN E. Conclusion: Deceleration Femoral bone Density during OSTEOPOROSIS will be accelerated with Decrease of VITAMIN E Antioxidant level.

Cites

THE PLASMA ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE ENZYME IN OSTEOPOROSIS

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APA: Copy

HAJI MAHMOUDI, MANAN, SADEGHI, N., MIRABZADEH, M., HAJI BABAEI, MOLOUK, JANAT, B., & JAMSHIDI, A.R.. (2007). VITAMIN E PLASMA CONCENTRATION IN OSTEOPOROTIC PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 65(1), 79-85. SID. https://sid.ir/paper/37985/en

Vancouver: Copy

HAJI MAHMOUDI MANAN, SADEGHI N., MIRABZADEH M., HAJI BABAEI MOLOUK, JANAT B., JAMSHIDI A.R.. VITAMIN E PLASMA CONCENTRATION IN OSTEOPOROTIC PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;65(1):79-85. Available from: https://sid.ir/paper/37985/en

IEEE: Copy

MANAN HAJI MAHMOUDI, N. SADEGHI, M. MIRABZADEH, MOLOUK HAJI BABAEI, B. JANAT, and A.R. JAMSHIDI, “VITAMIN E PLASMA CONCENTRATION IN OSTEOPOROTIC PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 65, no. 1, pp. 79–85, 2007, [Online]. Available: https://sid.ir/paper/37985/en

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