A NOVEL BIOINFORMATIC APPROACH FOR STAPHYLOCOCCAL VACCINE DEVELOPMENT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURMAND M.R.; FOSTER S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2006 | Volume:64 | Issue:6 Page(s): 19-26

Download Full-Text

Persian Verion

View:

1,319

Download:

Cites:

Information Journal Paper

Title

A NOVEL BIOINFORMATIC APPROACH FOR STAPHYLOCOCCAL VACCINE DEVELOPMENT

Author(s)

POURMAND M.R. | FOSTER S. | Issue Writer Certificate

Keywords

STAPHYLOCOCCUS AUREUSQ2

VACCINEQ2

BIOINFORMATICSQ2

Abstract

Background: STAPHYLOCOCCUS AUREUS and Staphylococcus epidermidis are major human pathogens of increasing importance due to the spread of antibiotic resistance. Novel potential targets for therapeutic antibodies are products of staphylococcal genes expressed during human infection. Previously, the secreted and surface-exposed proteins among seroreactive antigens have been discovered. Furthermore, approximately 60 immunogenic proteins were identified and have shown that bacterial surface display is uniquely suited to assess the value of the antigenic epitope. Methods: Using a bioinformatic analysis, a novel gene family was identified in STAPHYLOCOCCUS AUREUS and S. epidermidis. NCBI (National Center for Biotechnology Information) BLAST and TIGR search were used for identification of the loci on Staphylococcal genomes.Results: The members of nine gene family from S. aureus based on a conserved Cterminal domain following an N-terminal domain which varies in sequence and length.Further Blast P searches for paralogues revealed the novel Sca gene family in S.epidermidis has also highly conserved 110 amino acid C-terminal domain. Thus the Sca family has a conserved domain across different genera. Conclusion: Further studies to determine the role of the conserved Sca domain in ligand binding and demonstration of conserved epitope may establish the domain as a credible target for cross species vaccination.

Cites

CLONING, EXPRESSION AND PURIFICATION OF PENICILLIN BINDING PROTEIN2A (PBP2A) FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS: A STUDY ON IMMUNOREACTIVITY IN BALB/C MOUSE

References

No record.

Cite

APA: Copy

POURMAND, M.R., & FOSTER, S.. (2006). A NOVEL BIOINFORMATIC APPROACH FOR STAPHYLOCOCCAL VACCINE DEVELOPMENT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(6), 19-26. SID. https://sid.ir/paper/38028/en

Vancouver: Copy

POURMAND M.R., FOSTER S.. A NOVEL BIOINFORMATIC APPROACH FOR STAPHYLOCOCCAL VACCINE DEVELOPMENT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2006;64(6):19-26. Available from: https://sid.ir/paper/38028/en

IEEE: Copy

M.R. POURMAND, and S. FOSTER, “A NOVEL BIOINFORMATIC APPROACH FOR STAPHYLOCOCCAL VACCINE DEVELOPMENT,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 6, pp. 19–26, 2006, [Online]. Available: https://sid.ir/paper/38028/en

Related Journal Papers