OMEPRAZOLE VERSUS DOXYCYCLINE COMBINATION THERAPY WITH TOPICAL ERYTHROMYCIN THE TREATMENT OF ACNE VULGARIS: A RANDOMIZED CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAFFARY FARIBA; NILFOROUSHZADEH MOHAMMAD ALI; SHARIFIAN KOUPAIEE HANIEH; FAGHIHI GITA; HOSSEINI SEYED MOHSEN; SOKHANVARI FATEMEH; ANSARI NAZLI; SADEGHIAN GITI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2017 | Volume:75 | Issue:1 Page(s): 24-30

Download Full-Text

Persian Verion

View:

1,203

Download:

Cites:

Information Journal Paper

Title

OMEPRAZOLE VERSUS DOXYCYCLINE COMBINATION THERAPY WITH TOPICAL ERYTHROMYCIN THE TREATMENT OF ACNE VULGARIS: A RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

ACNE VULGARISQ3

CLINICAL TRIALQ3

DOXYCYCLINEQ3

OMEPRAZOLEQ3

Abstract

Background: ACNE VULGARIS is self-limiting, multifactorial disease involving sebaceous glands. OMEPRAZOLE is a proton pump inhibitor with in vitro antibacterial effects against staphylococcus aureusand anti-androgen that can be potential treatment of ACNE VULGARIS.This study was designed to evaluate the efficacy of oral OMEPRAZOLE and erythromycin 4% compared to DOXYCYCLINE combination therapy in the treatment of ACNE VULGARIS.Methods: In this CLINICAL TRIAL study, patients with moderate acne were referred to Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Science, Iran, during August 2014 until November 2015 and were randomized into two groups receiving topical erythromycin 4% plus OMEPRAZOLE (34 patients) or DOXYCYCLINE (35 patients) for 3 months. Moderate acne, lack of sensitivity to proton pump inhibitors, lack of warfarin, phenytoin, diazepam consumption, lack of active liver or kidney disease, being older than 12 years, were considered as inclusion criteria. Pregnant or lactating patients, patients with drug allergy history, patients taking oral contraceptives, acne topical medications (including retinoids) or systemic treatment within 30 days of study, patients with oligomenorrhea, hirsutism, acne conglobata, acne fulminant or body acne alone were excluded from the study. All patients were tested for Helicobacter pylori test at the beginning of the study.Results: Both inflammatory and non-inflammatory lesions decreased in both groups with negative correlation with age (P<0.05). There was no significant correlation between positive Helicobacter pylori test and inflammatory or non-inflammatory lesion reduction (P=0.794, P=0.514). Also, patient satisfaction and rate of total drug side effects was not different between two treatment groups. Rate of skin reactions was 20.58% in OMEPRAZOLE treated group and 11.42% in DOXYCYCLINE group. For side effects, other than skin it was 2.94% versus 14.28% respectively.Conclusion: OMEPRAZOLE could be suggested as an alternative for DOXYCYCLINE in the treatment of patients with moderate ACNE VULGARIS especially in non-inflammatory lesions.

Cites

No record.

References

No record.

Cite

APA: Copy

JAFFARY, FARIBA, NILFOROUSHZADEH, MOHAMMAD ALI, SHARIFIAN KOUPAIEE, HANIEH, FAGHIHI, GITA, HOSSEINI, SEYED MOHSEN, SOKHANVARI, FATEMEH, ANSARI, NAZLI, & SADEGHIAN, GITI. (2017). OMEPRAZOLE VERSUS DOXYCYCLINE COMBINATION THERAPY WITH TOPICAL ERYTHROMYCIN THE TREATMENT OF ACNE VULGARIS: A RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 75(1), 24-30. SID. https://sid.ir/paper/38061/en

Vancouver: Copy

JAFFARY FARIBA, NILFOROUSHZADEH MOHAMMAD ALI, SHARIFIAN KOUPAIEE HANIEH, FAGHIHI GITA, HOSSEINI SEYED MOHSEN, SOKHANVARI FATEMEH, ANSARI NAZLI, SADEGHIAN GITI. OMEPRAZOLE VERSUS DOXYCYCLINE COMBINATION THERAPY WITH TOPICAL ERYTHROMYCIN THE TREATMENT OF ACNE VULGARIS: A RANDOMIZED CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2017;75(1):24-30. Available from: https://sid.ir/paper/38061/en

IEEE: Copy

FARIBA JAFFARY, MOHAMMAD ALI NILFOROUSHZADEH, HANIEH SHARIFIAN KOUPAIEE, GITA FAGHIHI, SEYED MOHSEN HOSSEINI, FATEMEH SOKHANVARI, NAZLI ANSARI, and GITI SADEGHIAN, “OMEPRAZOLE VERSUS DOXYCYCLINE COMBINATION THERAPY WITH TOPICAL ERYTHROMYCIN THE TREATMENT OF ACNE VULGARIS: A RANDOMIZED CLINICAL TRIAL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 75, no. 1, pp. 24–30, 2017, [Online]. Available: https://sid.ir/paper/38061/en

Related Journal Papers