THE EFFECT OF INTRAVENOUS LIDOCAINE PREMEDICATION AND SLOW RATE OF FENTANYL ADMINISTRATION ON FENTANYL-INDUCED COUGHING

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TAREGH SH.A.H.; ZEYGHAMI D.; MAGHSOUDI B.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:14 | Issue:4 Page(s): 31-36

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Title

THE EFFECT OF INTRAVENOUS LIDOCAINE PREMEDICATION AND SLOW RATE OF FENTANYL ADMINISTRATION ON FENTANYL-INDUCED COUGHING

Author(s)

TAREGH SH.A.H. | ZEYGHAMI D. | MAGHSOUDI B. | Issue Writer Certificate

Keywords

FENTANYLQ3

COUGHQ3

LIDOCAINEQ3

INJECTION TIMEQ3

Abstract

Introduction: Intravenous (IV) administration of FENTANYL bolus elicits COUGH in more than one-third of the patients. COUGHs may sometimes be explosive leading to hypoxia, vomiting, with increases in intracranial, intraocular and intraabdominal pressures.Materials & Methods: This double blind clinical trial included 360 patients below 60 years with ASA status I & II, who were scheduled for elective surgeries. They were randomized into 3 groups of 120. Group I received Normal Saline as placebo, 60 secounds late FENTANYL was administred slowly over a period of 30 secounds. Group II was given FENTANYL over 5 secounds, 1 minute after LIDOCAINE, (1.5 mg/kg IV). Group III also received Normal Salin, 60 secounds before the FENTANYL was given in 5 secounds. FENTANYL dose was 2 mg/kg. Then, incidence and severity of COUGH was recorded, and the results were 0.05 was considered significant. £ analyzed using Chi square test. P.value ofResults: The incidence of COUGH was 2.5% in group I, 9.2% and 22.5% in groups II & III respectively. The finds showed that the incidence of COUGH was significantly higher in group III (P<0.001). Occurrence of COUGH in patients under 18 was more than those above 18 years of age in all the three groups (P=0.001).Conclusion: IV LIDOCAINE and, in particular, slow rate of FENTANYL administration, significantly minimize FENTANYL-Induced COUGHing. Also the incidence of evoked COUGH is much higher in young patients.

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APA: Copy

TAREGH, SH.A.H., ZEYGHAMI, D., & MAGHSOUDI, B.. (2007). THE EFFECT OF INTRAVENOUS LIDOCAINE PREMEDICATION AND SLOW RATE OF FENTANYL ADMINISTRATION ON FENTANYL-INDUCED COUGHING. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 14(4), 31-36. SID. https://sid.ir/paper/382077/en

Vancouver: Copy

TAREGH SH.A.H., ZEYGHAMI D., MAGHSOUDI B.. THE EFFECT OF INTRAVENOUS LIDOCAINE PREMEDICATION AND SLOW RATE OF FENTANYL ADMINISTRATION ON FENTANYL-INDUCED COUGHING. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;14(4):31-36. Available from: https://sid.ir/paper/382077/en

IEEE: Copy

SH.A.H. TAREGH, D. ZEYGHAMI, and B. MAGHSOUDI, “THE EFFECT OF INTRAVENOUS LIDOCAINE PREMEDICATION AND SLOW RATE OF FENTANYL ADMINISTRATION ON FENTANYL-INDUCED COUGHING,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4, pp. 31–36, 2007, [Online]. Available: https://sid.ir/paper/382077/en

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