Synthesis of Parthenolide-Melphalan Hybrid and Investigation of its Cytotoxicity Activity against Breast Cancer

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Karimi Ensiyeh; IRANSHAHI MEHRDAD; ALMASIRAD ALI; KARIMI EHSAN

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Journal: Jundishapur Scientific Medical Journal Year:2020 | Volume:19 | Issue:1 Page(s): 11-25

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Title

Synthesis of Parthenolide-Melphalan Hybrid and Investigation of its Cytotoxicity Activity against Breast Cancer

Author(s)

Karimi Ensiyeh | IRANSHAHI MEHRDAD | ALMASIRAD ALI | KARIMI EHSAN | Issue Writer Certificate

Keywords

Breast cancerQ2

MelphalanQ1

Sesquiterpene terpene lactonesQ1

ParthenolideQ1

Cytotoxicity activityQ2

Abstract

Background and Objective: Melphalan is a chemotherapy agent which used for treatment of metastatic melanoma and Breast cancer. However, the side effects associated with this compound have limited its clinical use. Parthenolide, a sesquiterpene lactone, is a bioactive compound from Tanacetum parthenium medicinal plant has anti-leukemia properties. Despite the many advantages of Sesquiterpene terpene lactones, these compounds have two obvious drawbacks: non-specificity for cancer cells and low solubility in water. Therefore, the aim of this study was to synthesis of a Parthenolide-Melphalan hybrid using conjugation method to enhance its anticancer potency. Moreover, the Cytotoxicity activity of this compound was tested against Breast cancer cell line (MDA-MB-231). Materials and Methods: In order to synthesis of mentioned compound, Melphalan was conjugated to Parthenolide sesquiterpene lactone by aza-Michael reaction. Then, the Cytotoxicity activity of this compound was tested using alamar blue assay. Results: The parthalan product synthesis of Melphalan anticancer drug and Parthenolide sesquiterpene were analysed and identified by LC-MS. The Cytotoxicity activity results indicated that cell viability of cancer cell (MDA-MB-231) was decreased in a dose-dependent manner and the IC50 of parthalan, Parthenolide and the synthesized hybrid were reported with respective values of 13. 5, 24 and 23 μ g/ml. Conclusion: The overall results of this research demonstrated that Parthenolide-Melphalan hybrid induce significantly enhanced the higher potency of Parthenolide.

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APA: Copy

Karimi, Ensiyeh, IRANSHAHI, MEHRDAD, ALMASIRAD, ALI, & KARIMI, EHSAN. (2020). Synthesis of Parthenolide-Melphalan Hybrid and Investigation of its Cytotoxicity Activity against Breast Cancer. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 19(1 ), 11-25. SID. https://sid.ir/paper/382148/en

Vancouver: Copy

Karimi Ensiyeh, IRANSHAHI MEHRDAD, ALMASIRAD ALI, KARIMI EHSAN. Synthesis of Parthenolide-Melphalan Hybrid and Investigation of its Cytotoxicity Activity against Breast Cancer. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2020;19(1 ):11-25. Available from: https://sid.ir/paper/382148/en

IEEE: Copy

Ensiyeh Karimi, MEHRDAD IRANSHAHI, ALI ALMASIRAD, and EHSAN KARIMI, “Synthesis of Parthenolide-Melphalan Hybrid and Investigation of its Cytotoxicity Activity against Breast Cancer,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 19, no. 1 , pp. 11–25, 2020, [Online]. Available: https://sid.ir/paper/382148/en

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