THE EFFECTS OF DURATION OF OLIVE LEAF EXTRACT ADMINISTRATION ON ISCHEMIA-INDUCED ARRHYTHMIAS RATS

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ESMAEEILI DAHEJ MANSOUR; KAKOO MOHADDESEH; REZVANI MOHAMMAD EBRAHIM; MIRHOSSEINI SEYED JALIL; MOSHTAGHIOON SEYED HOSSEIN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:95 Page(s): 57-64

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Title

THE EFFECTS OF DURATION OF OLIVE LEAF EXTRACT ADMINISTRATION ON ISCHEMIA-INDUCED ARRHYTHMIAS RATS

Author(s)

Keywords

OLIVE LEAF EXTRACTQ3

ARRHYTHMIAQ3

RATQ2

VENTRICULAR TACHYCARDIAQ2

VENTRICULAR FIBRILLATIONQ3

Abstract

Background and purpose: Many studies have investigated the cardio protective effects of OLIVE LEAF EXTRACT (OLE). None, however, has reported its antiarrhythmic role for in vivo model ARRHYTHMIA.This study aimed at investigating the antiarrhythmic effect of OLE and assessing the duration of its use in anesthetized RATs.Materials and methods: Forty eight male Wistar RATs were divided into six groups of eight. All groups-except group one (the control group)-received OLE (200 mg/kg/day, orally) for 1, 3, 7, 14 and 28 days, respectively. Then, their left anterior descending coronary artery (LAD) was occluded for 30 min under general anesthesia and artificial respiratory support. Direct blood pressure and electrocardiogram (ECG) were continuously monitored before and during the ischemia.Results: The data showed that severity of ARRHYTHMIA including ventricular ectopic beats, incidence of VENTRICULAR TACHYCARDIA (VT), and VENTRICULAR FIBRILLATION (VF) reduced significantly in groups that received OLE for at least 14 days. Also, the number and duration of VT and VF episodes decreased significantly in groups five and six, especially the group that received OLE for 28 days.Conclusion: These results show that oral administration of OLE could induce antiarrhythmic effect, if used for more than seven days. Further studies are required to determine the effects of different doses and durations and cellular mechanisms of OLE.

Cites

OLEUROPEIN CONTENT IN OLIVE LEAVES EXTRACT OF SPONGE CAKE

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APA: Copy

ESMAEEILI DAHEJ, MANSOUR, KAKOO, MOHADDESEH, REZVANI, MOHAMMAD EBRAHIM, MIRHOSSEINI, SEYED JALIL, & MOSHTAGHIOON, SEYED HOSSEIN. (2012). THE EFFECTS OF DURATION OF OLIVE LEAF EXTRACT ADMINISTRATION ON ISCHEMIA-INDUCED ARRHYTHMIAS RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(95), 57-64. SID. https://sid.ir/paper/382279/en

Vancouver: Copy

ESMAEEILI DAHEJ MANSOUR, KAKOO MOHADDESEH, REZVANI MOHAMMAD EBRAHIM, MIRHOSSEINI SEYED JALIL, MOSHTAGHIOON SEYED HOSSEIN. THE EFFECTS OF DURATION OF OLIVE LEAF EXTRACT ADMINISTRATION ON ISCHEMIA-INDUCED ARRHYTHMIAS RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(95):57-64. Available from: https://sid.ir/paper/382279/en

IEEE: Copy

MANSOUR ESMAEEILI DAHEJ, MOHADDESEH KAKOO, MOHAMMAD EBRAHIM REZVANI, SEYED JALIL MIRHOSSEINI, and SEYED HOSSEIN MOSHTAGHIOON, “THE EFFECTS OF DURATION OF OLIVE LEAF EXTRACT ADMINISTRATION ON ISCHEMIA-INDUCED ARRHYTHMIAS RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 95, pp. 57–64, 2012, [Online]. Available: https://sid.ir/paper/382279/en

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