Interleukin-6 Increased in Sera of Dialysis Patients with Severe Heart Failure

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Sanai Mohammad Nabi; SAMADIAN FARIBA; Jafari Fesharaki Mehrdad

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Journal: Research in Medicine Year:2020 | Volume:44 | Issue:1 Page(s): 291-295

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Title

Interleukin-6 Increased in Sera of Dialysis Patients with Severe Heart Failure

Author(s)

Sanai Mohammad Nabi | SAMADIAN FARIBA | Jafari Fesharaki Mehrdad | Issue Writer Certificate

Keywords

Chronic renal failureQ3

End stage renal diseaseQ1

EchocardiographyQ2

CRFQ1

ESRDQ1

IL-6Q2

Abstract

Background: Kidney failure is one of the most important health problems. The average life expectancy of dialysis patients is 3 to 5 years and the most common cause of death is cardiovascular events. Common risk factors for heart disease such as diabetes and hypertension alone do not justify the high risk of such events in these patients. The role of inflammation and the increase of inflammatory factors have been discussed more than other causes. Interleukin-6 has the strongest prognostic power to predict death in dialysis patients and is the best component of the expression of underlying inflammation. The purpose of the present study was to determine the association of interleukin-6 with echocardiographic findings in dialysis patients. Materials and Methods: In the current descriptive study, 52 adult patients (19 to 80 years old) with ESRD undergoing dialysis were selected from available samples. Data was provided with a checklist containing the variables studied including age, gender, duration of onset as well as underlying cause of kidney failure and history of heart disease. Interleukin 6 was determined using ELISA technique. Echocardiographic findings, including Ejection Fraction, inter ventricular septum diameter, and left ventricular end diastolic diameters, were all determined by one cardiologist using a fixed Echocardiography device. Data were analyzed using SPSS, version 23. Results: Dialysis patients with severe heart failure had higher levels of IL-6 than other dialysis patients (P-value= 0. 044). There was no significant relationship between serum interleukin 6 with inter ventricular septum diameter and left ventricular diastolic diameter. Conclusion: It seems that, IL-6, as an important factor, indicates severe heart failure and high mortality in dialysis patients. There is no relationship between the level of interleukin 6 and the ventricular septum and left ventricular diastolic diameter.

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APA: Copy

Sanai, Mohammad Nabi, SAMADIAN, FARIBA, & Jafari Fesharaki, Mehrdad. (2020). Interleukin-6 Increased in Sera of Dialysis Patients with Severe Heart Failure. PAJOUHESH DAR PEZESHKI, 44(1 ), 291-295. SID. https://sid.ir/paper/382590/en

Vancouver: Copy

Sanai Mohammad Nabi, SAMADIAN FARIBA, Jafari Fesharaki Mehrdad. Interleukin-6 Increased in Sera of Dialysis Patients with Severe Heart Failure. PAJOUHESH DAR PEZESHKI[Internet]. 2020;44(1 ):291-295. Available from: https://sid.ir/paper/382590/en

IEEE: Copy

Mohammad Nabi Sanai, FARIBA SAMADIAN, and Mehrdad Jafari Fesharaki, “Interleukin-6 Increased in Sera of Dialysis Patients with Severe Heart Failure,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 1 , pp. 291–295, 2020, [Online]. Available: https://sid.ir/paper/382590/en

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