HISTOLOGIC FINDINGS IN LIVER BIOPSY OF CHILDREN WITH THALASSEMIA MAJOR

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MAHJOUB F.; MOGHADDAM KA.; TAJZIEH CHI A.; ESMAEILI JAVID GH.R.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2004 | Volume:62 | Issue:8 Page(s): 630-636

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Title

HISTOLOGIC FINDINGS IN LIVER BIOPSY OF CHILDREN WITH THALASSEMIA MAJOR

Author(s)

MAHJOUB F. | MOGHADDAM KA. | TAJZIEH CHI A. | ESMAEILI JAVID GH.R. | Issue Writer Certificate

Keywords

THALASSEMIA MAJORQ4

LIVER BIOPSYQ4

FIBROSISQ4

IRON OVERLOADQ4

BONE MARROW TRANSPLANTATIONQ4

Abstract

Background: THALASSEMIA MAJOR is the most frequent hereditary anemia in Iran. In this study we wanted to evaluate liver status of these patients prior to BONE MARROW TRANSPLANTATION. Materials and Methods: Liver biopsies of 108 patients were evaluated for degree of iron deposition, FIBROSIS and inflammation, along with some clinical and paraclinical data.Results: In all of these patients some degree of iron deposition was found (16 percent had score 3 and 36 percent had score 4 of Marx and Sindram scoring system). FIBROSIS was seen in 68 percent of patients, mostly of mild to moderate degree (HAI score: 1 to 4 ) and only 3 patients had severe FIBROSIS (HAI score: 5 and 6). Inflammation was absent in 30 percent of patients and others had mild to moderate degree of inflammation. Serum ferritin level above 1500 Microgram per liter was strongly related to increased degree of iron load, FIBROSIS and inflammation. Conclusion: LIVER BIOPSY prior to BONE MARROW TRANSPLANTATION can be very useful in assessing degree of IRON OVERLOAD, FIBROSIS and inflammation.Conclusion: LIVER BIOPSY prior to BONE MARROW TRANSPLANTATION can be very useful in assessing degree IRON OVERLOAD, FIBROSIS and inflammation.

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APA: Copy

MAHJOUB, F., MOGHADDAM, KA., TAJZIEH CHI, A., & ESMAEILI JAVID, GH.R.. (2004). HISTOLOGIC FINDINGS IN LIVER BIOPSY OF CHILDREN WITH THALASSEMIA MAJOR. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(8), 630-636. SID. https://sid.ir/paper/38271/en

Vancouver: Copy

MAHJOUB F., MOGHADDAM KA., TAJZIEH CHI A., ESMAEILI JAVID GH.R.. HISTOLOGIC FINDINGS IN LIVER BIOPSY OF CHILDREN WITH THALASSEMIA MAJOR. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;62(8):630-636. Available from: https://sid.ir/paper/38271/en

IEEE: Copy

F. MAHJOUB, KA. MOGHADDAM, A. TAJZIEH CHI, and GH.R. ESMAEILI JAVID, “HISTOLOGIC FINDINGS IN LIVER BIOPSY OF CHILDREN WITH THALASSEMIA MAJOR,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 8, pp. 630–636, 2004, [Online]. Available: https://sid.ir/paper/38271/en

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