THE STUDY OF ANTINOCEPTION EFFECT OF HYDROALCOHOLIC EXTRACT OF LICORICE ROOT IN PHASIC AND TONIC MODELS OF PAIN IN MALE RATS

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ZAREEIAN P.; TAHERIANFARD M.

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Journal: Tehran University Medical Journal Year:2005 | Volume:62 | Issue:10 Page(s): 851-857

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Title

THE STUDY OF ANTINOCEPTION EFFECT OF HYDROALCOHOLIC EXTRACT OF LICORICE ROOT IN PHASIC AND TONIC MODELS OF PAIN IN MALE RATS

Author(s)

ZAREEIAN P. | | TAHERIANFARD M. | Issue Writer Certificate

Keywords

LICORICE ROOTQ4

FORMALIN TESTQ4

TAIL FLICK TESTQ4

PAINQ4

Abstract

Background: In the present time, analgesic and anti-inflammatory drugs such as nonsteroidal anti-inflammatory drugs and opioid compounds are used for the relief of PAIN, but due to their side-effects, economical issues, the significance of research on finding analgesic drugs with less side effects and their ability" to substitute these synthetic drugs, it seems necessary to search for newer analgesic compounds. In traditional Iranian medicine, rhizome of Glycyrrhiza glabra, is used as a topical medication in the treatment of inflammation and PAIN. Therefore, we decided to study the analgesic effects of this plant. Materials and Methods: Two methods-the TAIL FLICK TEST for acute PAIN and the FORMALIN TEST for chronic PAIN - were employed to measure PAIN. Analgesic effect of 100, 200 and 300 mg/Kg doses of Glycyrrhiza rhizome extract were compared with 300 mg/Kg soduim salicy late as a positive control. Results:The plant extract and soduin salicylate relieved PAIN in the second phase of FORMALIN TEST, but none of the two substances had analgesic effect in TAIL FLICK TEST. There were no significant differences between analgesic effect of plant extract and sodium salicylate. Conclusion: Based on the results, analgesic effect of plant extract is similar to sodium salicylate.

Cites

References

ANTI-INFLAMMATORY EFFECT OF LICORICE (LICORICE COMMON) ROOT EXTRACT ON ACUTE CARRAGEENAN-INDUCED INFLAMMATION IN RAT

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APA: Copy

ZAREEIAN, P., TAHERIANFARD, M.. (2005). THE STUDY OF ANTINOCEPTION EFFECT OF HYDROALCOHOLIC EXTRACT OF LICORICE ROOT IN PHASIC AND TONIC MODELS OF PAIN IN MALE RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(10), 851-857. SID. https://sid.ir/paper/38280/en

Vancouver: Copy

ZAREEIAN P., TAHERIANFARD M.. THE STUDY OF ANTINOCEPTION EFFECT OF HYDROALCOHOLIC EXTRACT OF LICORICE ROOT IN PHASIC AND TONIC MODELS OF PAIN IN MALE RATS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(10):851-857. Available from: https://sid.ir/paper/38280/en

IEEE: Copy

P. ZAREEIAN, M. TAHERIANFARD, “THE STUDY OF ANTINOCEPTION EFFECT OF HYDROALCOHOLIC EXTRACT OF LICORICE ROOT IN PHASIC AND TONIC MODELS OF PAIN IN MALE RATS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 10, pp. 851–857, 2005, [Online]. Available: https://sid.ir/paper/38280/en

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