Evaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease

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zahtabian Shahram; ali bakhshi Reza; seyedena Seyed yosuf; ray Alireza

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Journal: Journal of Medical Council of Iran Year:2020 | Volume:38 | Issue:1 Page(s): 34-41

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Title

Evaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease

Author(s)

zahtabian Shahram | ali bakhshi Reza | seyedena Seyed yosuf | ray Alireza | Issue Writer Certificate

Keywords

MiR-197Q1

Coronary Artery DiseaseQ1

Real Time RT-PCRQ1

Abstract

Background: Coronary Artery Disease (CAD) refers to the reduction or blockage of all or part of the coronary arteries due to the process of atherosclerosis or the presence of a clot. The aim of this study was to investigate the association of serum MiR-197 as a diagnostic index in patients with Coronary Artery Disease. Methods: In this study, 100 patients with CAD were selected. Extraction of microRNAs from peripheral blood plasma was performed using an exclusive microRNA extraction kit. Then the cDNA synthesis and the expression level of MiR-197 were performed using the Real Time RT-PCR technique and the SYBER Green method, using U6 snRNA as an internal control. T-test was used to analyze microRNA expression and significance and to determine the relationship between microRNA expression levels, Pearson correlation coefficient test was used. Results: The results showed a positive correlation between MiR-197 expression and CAD. The average expression of 0. 78 in the control sample was increased to 2. 76 according to severity of involvement in the patient. That is, the relative expression of MiR-197 in the patients + group was significantly increased compared to control (P <0. 004). Conclusion: It appears that MiR-197 can be considered as an indicator of coronary endothelial cell function. It is possible to use it as a bio marker for prognosis, and control of treatment for CAD.

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APA: Copy

zahtabian, Shahram, ali bakhshi, Reza, seyedena, Seyed yosuf, & ray, Alireza. (2020). Evaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 38(1 ), 34-41. SID. https://sid.ir/paper/383420/en

Vancouver: Copy

zahtabian Shahram, ali bakhshi Reza, seyedena Seyed yosuf, ray Alireza. Evaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2020;38(1 ):34-41. Available from: https://sid.ir/paper/383420/en

IEEE: Copy

Shahram zahtabian, Reza ali bakhshi, Seyed yosuf seyedena, and Alireza ray, “Evaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 38, no. 1 , pp. 34–41, 2020, [Online]. Available: https://sid.ir/paper/383420/en

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