Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage

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KHAJAVI MARYAM; Hajimoradloo Abdolmajid; ZANDI MOJGAN; PEZESHKI MODARESS MOHAMAD; ZAMANI ABBAS; BONAKDAR SHAHIN

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Journal: JOURNAL OF FISHERIES SCIENCE AND TECHNOLOGY (JFST) Year:2020 | Volume:9 | Issue:3 Page(s): 201-211

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Title

Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage

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Keywords

Micro-particleQ1

Double emulsionQ1

HydrogelQ1

PCLQ1

BSAQ1

Abstract

Controlled delivery technology of protein/peptide drugs from biodegradable particles has emerged as one of the eminent areas to overcome problems related to macromolecules formulation. The goal of the present study was to develop protein-loaded Micro-particles using biodegradable polymer, polycaprolactone (PCL) and Hydrogel from beluga cartilage. Bovine serum albumin (BSA) was used as a model for protein/ peptide molecules such as GnRH. The Double emulsion (W/O/W) technique was selected as one of the most appropriate methods for preparing a drug delivery system for soluble proteins in water. The first emulsion was prepared using ultrasonic and the mechanical agitator was used for achieving the second emulsion. The Hydrogel prepared by enzymatic digestion was used in the first aquatic solution. At the present investigation, three groups were considered as the drug delivery system: G1; (PCL/Hydrogel/BSA), G2; (PCL/BSA) and G3; (PCL/Alginate/BSA). Findings showed that the morphology of particles was spherical and non-conglomerated in all groups. The comparison of average particle size among groups was also indicated that the particles.

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APA: Copy

KHAJAVI, MARYAM, Hajimoradloo, Abdolmajid, ZANDI, MOJGAN, PEZESHKI MODARESS, MOHAMAD, ZAMANI, ABBAS, & BONAKDAR, SHAHIN. (2020). Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage. JOURNAL OF FISHERIES SCIENCE AND TECHNOLOGY (JFST), 9(3 ), 201-211. SID. https://sid.ir/paper/383754/en

Vancouver: Copy

KHAJAVI MARYAM, Hajimoradloo Abdolmajid, ZANDI MOJGAN, PEZESHKI MODARESS MOHAMAD, ZAMANI ABBAS, BONAKDAR SHAHIN. Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage. JOURNAL OF FISHERIES SCIENCE AND TECHNOLOGY (JFST)[Internet]. 2020;9(3 ):201-211. Available from: https://sid.ir/paper/383754/en

IEEE: Copy

MARYAM KHAJAVI, Abdolmajid Hajimoradloo, MOJGAN ZANDI, MOHAMAD PEZESHKI MODARESS, ABBAS ZAMANI, and SHAHIN BONAKDAR, “Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage,” JOURNAL OF FISHERIES SCIENCE AND TECHNOLOGY (JFST), vol. 9, no. 3 , pp. 201–211, 2020, [Online]. Available: https://sid.ir/paper/383754/en

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