EFFECTS OF KERACK USED IN ADDICT IRANIAN PEOPLE ON FERTILITY OF ADULT MICE

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AMINI MEHDI; ROGHANI MEHRDAD; SHIRINBAYAN PEYMANEH; JOGHATAIE MOHAMMAD TAGHI; FARHOUDIAN ALI; ROSHANPAJOUH MOHSEN; KORUJI MORTEZA

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2013 | Volume:71 | Issue:5 Page(s): 293-302

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Title

EFFECTS OF KERACK USED IN ADDICT IRANIAN PEOPLE ON FERTILITY OF ADULT MICE

Author(s)

Keywords

ILLICIT SUBSTANCEQ3

SPERM PARAMETERSQ2

TESTISQ2

Abstract

Background: Infertility is one of the most serious social problems. Illicit drug use can be an important cause of male factor infertility. Kerack which its use is rising up in Iran refers to a high purity street-level heroin (heroin Kerack). Heroin Kerack used in Iran is an opioid and has harmful effects on body organs. The aim of this study is to investigate the effects of Kerack used in Iran on fertility adult mice.Methods: In this study, 25 male mice were divided into five groups (control, sham and three experimental). Experimental groups of Kerack-dependent mice (received ascending dose of Kerack for seven days) were divided into three categories, experimental I, II and III. Experimental I was given Kerack at a dose of 5 mg/kg, experimental II 35 mg/kg and experimental III 70 mg/kg, intraperitoneally twice a day for a period of 35 days. The sham group received normal saline and lemon juice (2.6 ml/ml) whilst the control group just received water and food. Mice were then scarified and sperm removed from cauda epididymis were analyzed for sperm count, motility, morphology (normal/abnormal) and viability. Testes were also removed, weighed and processed for light microscopic studies.Results: The results showed that fertility were significantly decreased in addicted mice compared with control groups (P£0.05). Epididymal SPERM PARAMETERS and thickness of seminiferous epithelium were significantly decreased in experimental groups (dosedependent) compared with sham and control groups (P£0.05). Gonadosomatic index was significantly reduced with high dose Kerack injected (70 mg/kg) in comparison with control testes (P£0.05).Conclusion: This study has shown the deleterious effects of Kerack used in addicted Iranian people on fertility for the first time. This effect is especially on epididymal SPERM PARAMETERS in adult mice.

Cites

Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men

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APA: Copy

AMINI, MEHDI, ROGHANI, MEHRDAD, SHIRINBAYAN, PEYMANEH, JOGHATAIE, MOHAMMAD TAGHI, FARHOUDIAN, ALI, ROSHANPAJOUH, MOHSEN, & KORUJI, MORTEZA. (2013). EFFECTS OF KERACK USED IN ADDICT IRANIAN PEOPLE ON FERTILITY OF ADULT MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(5), 293-302. SID. https://sid.ir/paper/38376/en

Vancouver: Copy

AMINI MEHDI, ROGHANI MEHRDAD, SHIRINBAYAN PEYMANEH, JOGHATAIE MOHAMMAD TAGHI, FARHOUDIAN ALI, ROSHANPAJOUH MOHSEN, KORUJI MORTEZA. EFFECTS OF KERACK USED IN ADDICT IRANIAN PEOPLE ON FERTILITY OF ADULT MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(5):293-302. Available from: https://sid.ir/paper/38376/en

IEEE: Copy

MEHDI AMINI, MEHRDAD ROGHANI, PEYMANEH SHIRINBAYAN, MOHAMMAD TAGHI JOGHATAIE, ALI FARHOUDIAN, MOHSEN ROSHANPAJOUH, and MORTEZA KORUJI, “EFFECTS OF KERACK USED IN ADDICT IRANIAN PEOPLE ON FERTILITY OF ADULT MICE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 5, pp. 293–302, 2013, [Online]. Available: https://sid.ir/paper/38376/en

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