The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer

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Mansoor Lakooraj Hamed; KHAKI ZOHREH; GHORBANI MASOUD; SHAFIEE ARDESTANI MEHDI; DEZFOULIAN OMID

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Journal: Iranian Journal of Veterinary Medicine Year:2020 | Volume:14 | Issue:2 Page(s): 147-158

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Title

The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer

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Keywords

ApoptosisQ1

BaxQ1

Bcl2Q1

Breast cancerQ1

Doxorubicine-G2-folateQ1

Abstract

BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as Breast cancer. OBJECTIVES: The present study aimed to evaluate the effect of Doxorubicine-G2-FA (Dox-G2-FA) with in vitro assays. The abbreviation of G2 represents the second generation of dendrimer synthesis. METHODS: For this purpose, Dox-G2-FA was synthesized and mass spectroscopy was used to confirm the synthesized component. Also, MTT assay, flow cytometry, and gene expression assay by real-time PCR were used to evaluate cell viability, Apoptosis, and necrosis. RESULTS: In this study, the effect of Dox and Dox-G2-FA on the expression of Bax, Bcl2 genes showed that there was a significant decrease in the expression of the Bcl2 gene in the Dox-G2-FA group compared to Dox and control groups(P<0. 05). Also, the results of flow-cytometry showed that Apoptosis in the presence of Dox-G2-FA was greater than in the Dox group (P<0. 05). CONCLUSIONS: Therefore, it seems that the effect of Dox-G2-FA on Apoptosis is better than the effect of Dox usage alone.

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APA: Copy

Mansoor Lakooraj, Hamed, KHAKI, ZOHREH, GHORBANI, MASOUD, SHAFIEE ARDESTANI, MEHDI, & DEZFOULIAN, OMID. (2020). The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 14(2 ), 147-158. SID. https://sid.ir/paper/383772/en

Vancouver: Copy

Mansoor Lakooraj Hamed, KHAKI ZOHREH, GHORBANI MASOUD, SHAFIEE ARDESTANI MEHDI, DEZFOULIAN OMID. The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2020;14(2 ):147-158. Available from: https://sid.ir/paper/383772/en

IEEE: Copy

Hamed Mansoor Lakooraj, ZOHREH KHAKI, MASOUD GHORBANI, MEHDI SHAFIEE ARDESTANI, and OMID DEZFOULIAN, “The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 14, no. 2 , pp. 147–158, 2020, [Online]. Available: https://sid.ir/paper/383772/en

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