DETERMINATION OF THE ACUTE AND PERSISTENT EFFECTS OF ALUMINUM ON MEMORY AND LEARNING ABILITIES OF RAT

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ALAEI H.; MOSHTAGHI A.A.; REZAEI KH.

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Journal: Journal of Kerman University of Medical Sciences Year:2001 | Volume:8 | Issue:3 Page(s): 137-146

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Title

DETERMINATION OF THE ACUTE AND PERSISTENT EFFECTS OF ALUMINUM ON MEMORY AND LEARNING ABILITIES OF RAT

Author(s)

ALAEI H. | MOSHTAGHI A.A. | REZAEI KH. | Issue Writer Certificate

Keywords

AL3++Q4

MEMORYQ2

LEARNINGQ2

EEGQ3

RATQ2

Abstract

In regard to the role of Aluminum in the emergence of psychological disorders in patients with chronic kidney diseases, this research project studied the acute, and chronic effects of aluminum on MEMORY and LEARNING abilities of RAT. In order to determine the short and lengthen effects of aluminum on different stages of MEMORY and LEARNING abilitis, after grouping the RATs Aluminum chloride with concentrations of 1mg, 5mg, 10mg and 20mg was used per kg of body weight. The aluminum was given by intraperitoneal injection during g phases of 30 days, 60 days and 90 days and following this a shuttle box was used to evaluate its effects on MEMORY and LEARNING abilities. The results indicated that plasma level of aluminum was significantly increased, however Aluminum at 90.mg/kg had no significant effect on the RAT's ability of LEARNING. However doses of 1, 5, 10 mg/kg clearly had a significant inhibitory effect on MEMORY and LEARNING abilities. This inhibitory effect had a-direct correlation with-the duration and dose of the aluminum injection. The highest inhibitory effect on MEMORY and LEARNING abilities was achieved at 15mg/kg dose at 30 and 45 days, which was 34.5 and 52.3%-respectively (P<0.05) Injection of 2mg/kg of arecholine caused an increase of 25% in-learning abilitis and was statistically significant in comparison to the control group (P<0.05). It can be concluded from this study that aluminum have an inhibitory effect on metabolism of nerve cells, and induces alterations on MEMORY level and RAT's LEARNING ability, these changes completely depended on the concentration and duration of exposure to aluminum.

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APA: Copy

ALAEI, H., MOSHTAGHI, A.A., & REZAEI, KH.. (2001). DETERMINATION OF THE ACUTE AND PERSISTENT EFFECTS OF ALUMINUM ON MEMORY AND LEARNING ABILITIES OF RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 8(3), 137-146. SID. https://sid.ir/paper/384/en

Vancouver: Copy

ALAEI H., MOSHTAGHI A.A., REZAEI KH.. DETERMINATION OF THE ACUTE AND PERSISTENT EFFECTS OF ALUMINUM ON MEMORY AND LEARNING ABILITIES OF RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;8(3):137-146. Available from: https://sid.ir/paper/384/en

IEEE: Copy

H. ALAEI, A.A. MOSHTAGHI, and KH. REZAEI, “DETERMINATION OF THE ACUTE AND PERSISTENT EFFECTS OF ALUMINUM ON MEMORY AND LEARNING ABILITIES OF RAT,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 3, pp. 137–146, 2001, [Online]. Available: https://sid.ir/paper/384/en

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