THE EFFECT OF D2 AGONIST VERSUS D2 ANTAGONIST ON THE FEAR BEHAVIOR IN THE MALE RATS USING PLUS-MAZE METHOD: THE PROSPECTIVE STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SABZEHKHAH S.; VAEZI GH.H.; BAKHTIARIAN A.; SALARIAN A.; ZARE HAGHIGHI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2009 | Volume:67 | Issue:8 Page(s): 535-541

Download Full-Text

Persian Verion

View:

1,565

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF D2 AGONIST VERSUS D2 ANTAGONIST ON THE FEAR BEHAVIOR IN THE MALE RATS USING PLUS-MAZE METHOD: THE PROSPECTIVE STUDY

Author(s)

Keywords

FEARQ3

DOPAMINERGICQ3

SULPIRIDEQ3

BROMOCRIPTINEQ3

INTRAVENTRICULAR INJECTIONQ3

RATQ3

Abstract

Background: DOPAMINERGIC is the most important neurotransmitter is FEAR. The DOPAMINERGIC mesolimbic pathway has essential role in excitable behavior, and its role in Parkinson disease. The aim of this research in study, the effect of DOPAMINERGIC pathway in FEAR response.Methods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze (OAT%) and the percentage of entries into the open arms (OAE%) to measure FEAR. Increases in the OAT% and OAE% indicate an anxiolytic effect (reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. After five days, the RATs were injected with saline and different doses of SULPIRIDE and BROMOCRIPTINE.Results: Results showed that intracerebroventricular administration of SULPIRIDE, in the doses of 5, 20mg/rat and BROMOCRIPTINE, D2 agonist in doses 65, 95μg/rat produced a significant effect comparing to sham groups (p<0.05). While intracerebroventricular administration of SULPIRIDE 15, 10mg/rat, and BROMOCRIPTINE 70, 80mg/rat, did not show any significant effect comparing with sham group (p<0.05). In the current research intracerebroventricular administration of SULPIRIDE, D2 antagonist at the doses of 5, 10, 15, 20mg/rat and BROMOCRIPTINE, D2 agonist in the doses of 65, 70, 80, 95mg/rat were used and theire effect on the FEAR behavior were studied.Conclusions: The possible effect of DOPAMINERGIC system in the FEAR process, especially D2 receptor increase FEAR.

Cites

No record.

References

No record.

Cite

APA: Copy

SABZEHKHAH, S., VAEZI, GH.H., BAKHTIARIAN, A., SALARIAN, A., & ZARE HAGHIGHI, M.. (2009). THE EFFECT OF D2 AGONIST VERSUS D2 ANTAGONIST ON THE FEAR BEHAVIOR IN THE MALE RATS USING PLUS-MAZE METHOD: THE PROSPECTIVE STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(8), 535-541. SID. https://sid.ir/paper/38453/en

Vancouver: Copy

SABZEHKHAH S., VAEZI GH.H., BAKHTIARIAN A., SALARIAN A., ZARE HAGHIGHI M.. THE EFFECT OF D2 AGONIST VERSUS D2 ANTAGONIST ON THE FEAR BEHAVIOR IN THE MALE RATS USING PLUS-MAZE METHOD: THE PROSPECTIVE STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(8):535-541. Available from: https://sid.ir/paper/38453/en

IEEE: Copy

S. SABZEHKHAH, GH.H. VAEZI, A. BAKHTIARIAN, A. SALARIAN, and M. ZARE HAGHIGHI, “THE EFFECT OF D2 AGONIST VERSUS D2 ANTAGONIST ON THE FEAR BEHAVIOR IN THE MALE RATS USING PLUS-MAZE METHOD: THE PROSPECTIVE STUDY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 8, pp. 535–541, 2009, [Online]. Available: https://sid.ir/paper/38453/en

Related Journal Papers