NEOADJUVANT CHEMO RADIATION WITH CAPCITABINE AND CELECOXIB IN STAGE II AND III RECTAL ADENOCARCINOMA

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AGHILI MEHDI; BABAEI MOHAMMAD; AZMOODEH ARDALAN FARID; FARHAN FARSHID; HADAD PEYMAN; GANJALIKHANI MARYAM

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2010 | Volume:68 | Issue:7 Page(s): 391-397

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Title

NEOADJUVANT CHEMO RADIATION WITH CAPCITABINE AND CELECOXIB IN STAGE II AND III RECTAL ADENOCARCINOMA

Author(s)

Keywords

RECTAL CANCERQ3

CELECOXIBQ3

TUMOR REGRESSION GRADEQ3

NEOADJUVANT CHEMO RADIATIONQ3

Abstract

Background: ColoRECTAL CANCER is the third common cancer world wide and the forth in Iran. Neoadjuvant chemo radiotherapy is the standard treatment for locally advanced RECTAL CANCER. In this study we evaluate the efficacy a cox-2 inhibitor on pathologic response, sphincter preservation and acute toxicity during NEOADJUVANT CHEMO RADIATION.Methods: Thirty-six patients that have adenocarcinoma of rectum was enrolled (up to 15cm of anal verge). The patients were undergone Endometrial Ultrasound (EUS), abdomino-pelvic and chestCT for staging. Then received neoadjuvant concurrent chemo radiation (xeloda825 mg/m2 bid in combination with CELECOXIB 100 mg qid and 50-50.4 Gy/25-28 f). Surgery was done 4-8 weeks after chemo radiation. During the chemo radiation the patients was observed for the probable complication one year.Tumor regression grade was reported.Results: From 36 surgery patients, Total Mesorectal Excision (TME) was done in 30 patients. Pathologic complete response was seen in eight of 30 patients (26.7%). TUMOR REGRESSION GRADE was calculated in three and five grade system: in three grade system 17 patients had grade 1 (60.7%), eight patients had grade 2 (28.6%) and three patients had grade 3 (10.7%). In five grade system of tumor regression eight patients had grade 1 (28.6%), nine patients had grade 2 (32.1%), eight patients grade 3 (28.6%), three patients had grade 4 (10.7%). T down staging was 43.3%. N down staging was 30.8%. No patient had skin reaction or cardio-vascular complication.Conclusion: Based on our study results, CELECOXIB in combination with NEOADJUVANT CHEMO RADIATION is safe and is associated with low complications. This combination can promote pathologic complete response, TRG and T and N down staging in Rectal adenocarcinoma.

Cites

THE ROLE OF SELECTIVE COX-2 INHIBITORS ON HIF-1 ALPHA GENE IN COLORECTAL CANCER: AN IN-VITRO STUDY

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APA: Copy

AGHILI, MEHDI, BABAEI, MOHAMMAD, AZMOODEH ARDALAN, FARID, FARHAN, FARSHID, HADAD, PEYMAN, & GANJALIKHANI, MARYAM. (2010). NEOADJUVANT CHEMO RADIATION WITH CAPCITABINE AND CELECOXIB IN STAGE II AND III RECTAL ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(7), 391-397. SID. https://sid.ir/paper/38492/en

Vancouver: Copy

AGHILI MEHDI, BABAEI MOHAMMAD, AZMOODEH ARDALAN FARID, FARHAN FARSHID, HADAD PEYMAN, GANJALIKHANI MARYAM. NEOADJUVANT CHEMO RADIATION WITH CAPCITABINE AND CELECOXIB IN STAGE II AND III RECTAL ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(7):391-397. Available from: https://sid.ir/paper/38492/en

IEEE: Copy

MEHDI AGHILI, MOHAMMAD BABAEI, FARID AZMOODEH ARDALAN, FARSHID FARHAN, PEYMAN HADAD, and MARYAM GANJALIKHANI, “NEOADJUVANT CHEMO RADIATION WITH CAPCITABINE AND CELECOXIB IN STAGE II AND III RECTAL ADENOCARCINOMA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 7, pp. 391–397, 2010, [Online]. Available: https://sid.ir/paper/38492/en

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