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Information Journal Paper

Title

Association of DLA-DRB1 Alleles and Canine Atopic Dermatitis

Pages

  390-398

Keywords

MHCQ1
DogQ2

Abstract

 BACKGROUND: Major histocompatibility complex (MHC) is a group of genes which codes for binding of antigenic peptides and presenting them to T cells. MHC molecules polymorphism is associated with presenting different antigens, immune and autoimmune responses. One of the most important Dog MHC genes is DRB1. The association between this gene and its Alleles with Atopic Dermatitis has been reported. OBJECTIVES: In this study, the association between canine Atopic Dermatitis and DLA-DRB1 Alleles has been evaluated using HRM (High Resolution Melting) genotyping method. METHODS: Blood samples were collected from 20 Dogs with Atopic Dermatitis and 20 healthy Dogs. Frequency of different DRB1 genotypes, as well as heterozygosity and homozygosity of Alleles were analyzed using HRM. Their associations with Atopic Dermatitis were evaluated by statistical analysis. RESULTS: Based on the HRM analysis, genotypes were grouped in 9 types (A-I). Statistical analysis showed that the presence of type D Allele in the exon II of DLA-DRB1 gene increases the risk of Atopic Dermatitis (Odd ratio=0. 206 and P=0. 064). A significantly increased risk of Atopic Dermatitis in heterozygous samples was also observed (Odd=0. 158 and P=0. 090). CONCLUSIONS: The results of this study showed that some Alleles of DLA-DRB1 gene can play a role in the sensitivity or resistance to Atopic Dermatitis in Dogs.

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    • Cite

    APA: Copy

    Bozorgpanah, Shadi, JAMSHIDI, SHAHRAM, VAHEDI, SEYED MILAD, Lankarani Mohajer, Leila, & Nikbakht Brujeni, Gholamreza. (2020). Association of DLA-DRB1 Alleles and Canine Atopic Dermatitis. JOURNAL OF VETERINARY RESEARCH, 75(3 ), 390-398. SID. https://sid.ir/paper/385296/en

    Vancouver: Copy

    Bozorgpanah Shadi, JAMSHIDI SHAHRAM, VAHEDI SEYED MILAD, Lankarani Mohajer Leila, Nikbakht Brujeni Gholamreza. Association of DLA-DRB1 Alleles and Canine Atopic Dermatitis. JOURNAL OF VETERINARY RESEARCH[Internet]. 2020;75(3 ):390-398. Available from: https://sid.ir/paper/385296/en

    IEEE: Copy

    Shadi Bozorgpanah, SHAHRAM JAMSHIDI, SEYED MILAD VAHEDI, Leila Lankarani Mohajer, and Gholamreza Nikbakht Brujeni, “Association of DLA-DRB1 Alleles and Canine Atopic Dermatitis,” JOURNAL OF VETERINARY RESEARCH, vol. 75, no. 3 , pp. 390–398, 2020, [Online]. Available: https://sid.ir/paper/385296/en

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