THE EFFECT OF PROBIOTICS ON SIGNALING PATHWAYS OF GENESINVOLVED IN DEPRESSION: REVIEW ARTICLE

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FARZANEH SAHAR; TAFVIZI FARZANEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2018 | Volume:76 | Issue:3 Page(s): 155-161

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Title

THE EFFECT OF PROBIOTICS ON SIGNALING PATHWAYS OF GENESINVOLVED IN DEPRESSION: REVIEW ARTICLE

Author(s)

FARZANEH SAHAR | TAFVIZI FARZANEH | Issue Writer Certificate

Keywords

DEPRESSIONQ2

GENETICQ3

PHYSIOLOGYQ1

PROBIOTICSQ2

Abstract

DEPRESSION is the psychological disorder which caused by chronic stress and extensivecommunication network between the gastrointestinal system via the “ gut– brainmicrobiotaaxis” . DEPRESSION can systematically activate/deactivate many genes andsignaling molecules involved in the pathogenesis of the gastrointestinal disease. Whereas, most of the anti-depressant drugs suppress the DEPRESSION symptoms by alteringthe neurotransmitters activity; studies on PROBIOTICS have shown the anti-depressantpotential of them. Nutritional psychiatry is a field of psychiatry that investigates therelationship between dietary patterns and risk of mental disorders. The special type ofprobiotic has been identified to improve a number of diseases, such as diabetes, obesity, gastrointestinal infections, cancers, reduction of allergies and mood disorders such asDEPRESSION. There is an evidence about therapeutic effects of PROBIOTICS in symptoms ofDEPRESSION, but because of the low number of samples, the limitation in use of differentstrains of bacteria and the limited laboratory equipment, it is difficult to make a definitiveview about these results and need to more clinical study to determine the effectivedose of PROBIOTICS in the treatment of DEPRESSION. The articles related to this subjectwere collected from reliable database till the 2017 year, new studies and reviews articleswhich determine the effects of PROBIOTICS on the treatment of digestive and neurologicaldiseases. The objective of this review is to study the current clinical researchabout the effects of PROBIOTICS in the treatment of symptoms of DEPRESSION and discussfuture directions in this field. Most of the studies demonstrated PROBIOTICS’ ability toimproving mood, change behavior and improve the symptoms of stress and DEPRESSIONsuch as insomnia by increasing of serotonin and reducing of inflammation; and modulationof emotional behavior with effect on specific cytokines in brain. It has been discoveredthat PROBIOTICS have therapeutic effects extend beyond the gut and into the centralnervous system by influence signaling pathways. In conclusion, it seems they havethe potential to be used as a dietary supplement to optimize and enriched the food productsand effective step in the prevention and treatment of various disorders in the nervoussystem instead of chemical drugs.

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