Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences

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SAKI JASEM; ARJMAND REZA; Etebar Hossein; AHANGARPOUR AKRAM; Tavalla Mehdi; OROOJAN ALI AKBAR

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Journal: Jundishapur Scientific Medical Journal Year:2018 | Volume:17 | Issue:5 Page(s): 457-465

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Title

Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences

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Keywords

GiardiasisQ3

Vitamin DQ2

Type 2 diabetesQ2

PatientQ2

AhvazQ3

Abstract

Background and Objective: Giardiasis is a parasitic disease produced by Giardia lamblia can lead to malabsorption of Vitamin D and in turn, deficiency of this vitamin increases the risk of development of Type 2 diabetes. The objective of the present study was to investigate the effect of chronic Giardiasis on the status of Vitamin D and the risk of type2 diabetes in Patients suffering from chronic Giardiasis. Subjects and Methods: Sixty Patients referred to the clinical laboratories of the educational hospitals of Ahvaz Jundishapur University of Medical Sciences were voluntarily enrolled in this case-control study. After confirmation of giardia parasite infection by direct and blood sampling from Patients, plasma sample was isolated, and the levels of Vitamin D, glucose, insulin, lipid factors, liver enzymes were evaluated. In addition, the insulin resistance index (HOMA-IR), beta-cell function index (HOMA-β ), insulin sensitivity index (QUICKI) were assessed. Furthermore, the liver enzymes (AST, ALT and ALP) were determined for both groups. Results: Plasma level of Vitamin D in Patients with Giardiasis was significantly lower than healthy subjects (P <0. 05). Although insulin level did not increase in these Patients, glucose (P<0. 001) and HOMA-IR (P<0. 05) increased significantly in these Patients. While HOMA-β , QUICKI and DI decreased significantl in Patients with Giardiasis (P <0. 05). The values of AST (P <0. 001), ALT (P <0. 01) and ALP (P <0. 05) enzymes were significantly higher in Patients with Giardiasis. Conclusion: The overall result of this study indicates that chronic Giardiasis leads to a decrease in Vitamin D level and an increase in the variables related to type2 diabetes. In addition, there are direct correlation between both chronic Giardiasis and decrease in Vitamin D and the increase in activity of liver enzymes.

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APA: Copy

SAKI, JASEM, ARJMAND, REZA, Etebar, Hossein, AHANGARPOUR, AKRAM, Tavalla, Mehdi, & OROOJAN, ALI AKBAR. (2018). Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(5 ), 457-465. SID. https://sid.ir/paper/385730/en

Vancouver: Copy

SAKI JASEM, ARJMAND REZA, Etebar Hossein, AHANGARPOUR AKRAM, Tavalla Mehdi, OROOJAN ALI AKBAR. Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(5 ):457-465. Available from: https://sid.ir/paper/385730/en

IEEE: Copy

JASEM SAKI, REZA ARJMAND, Hossein Etebar, AKRAM AHANGARPOUR, Mehdi Tavalla, and ALI AKBAR OROOJAN, “Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 5 , pp. 457–465, 2018, [Online]. Available: https://sid.ir/paper/385730/en

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