BLOOD ANTIOXIDANT LEVELS AND ALTERATIONS OF SERUM CALCIUM AND PH IN HEMODIALYSIS PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEMATI MAHDI; KADKHODAEI MEHRI; ZAHMATKESH M.; MAHDAVI MAZDEH M.; GHAZNAVI R.; MIRERSHADI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2008 | Volume:66 | Issue:1 Page(s): 12-17

Download Full-Text

Persian Verion

View:

1,498

Download:

Cites:

Information Journal Paper

Title

BLOOD ANTIOXIDANT LEVELS AND ALTERATIONS OF SERUM CALCIUM AND PH IN HEMODIALYSIS PATIENTS

Author(s)

Keywords

HEMODIALYSISQ3

OXIDATIVE STRESSQ2

ANTIOXIDANTQ2

Abstract

Background: The risk of atherosclerosis and cancer is high in HEMODIALYSIS (HD) patients. There is evidence that HD causes OXIDATIVE STRESS. However, the causative factors of OXIDATIVE STRESS are unknown. It has been suggested that HD imposes an additional OXIDATIVE STRESS on patients with chronic renal failure by activation of granulocytes on dialyzer membranes resulting in an imbalance between oxidants and ANTIOXIDANTs. In this regard, a number of reports, either measuring specific analytes or enzymes, or estimating the total ANTIOXIDANT activity of the plasma have given contradictory and inconclusive results. To investigate the OXIDATIVE STRESS status in Iranian HD patients, in this study, we evaluated GSH and FRAP levels along with Ca and pH in the blood of these patients.Methods: Along with 20 healthy age and gender matched control subjects, 24 patients underwent dialysis, three times per week, for four hours in each session. Before and after dialysis, blood was taken for biochemical and liver function tests and to evaluate OXIDATIVE STRESS markers and measure Ca and pH levels.Results: There was a significant decrease in FRAP and GSH levels after dialysis compared to those before treatment. Dialysis caused an increase in pH and Ca levels compared to levels in control subjects after dialysis.Conclusion: In general, before dialysis, there is a balance between oxidants and ANTIOXIDANTs; however, due to higher levels of oxidants as well as the possible binding of ANTIOXIDANTs to the dialyzer membrane during dialysis, an imbalance occurs. The instability in the balance of oxidants and ANTIOXIDANTs may be the major cause of cellular oxidative damage found in HD patients. This study indicates that there is a significant level of OXIDATIVE STRESS in renal chronic patients and this stress is augmented by dialysis. ANTIOXIDANT therapy should be considered in these patients.

Cites

GLUTATHIONE, GLUTATHIONE-RELATED ENZYMES, AND TOTAL ANTIOXIDANT CAPACITY IN PATIENTS ON MAINTENANCE DIALYSIS

References

No record.

Cite

APA: Copy

HEMATI, MAHDI, KADKHODAEI, MEHRI, ZAHMATKESH, M., MAHDAVI MAZDEH, M., GHAZNAVI, R., & MIRERSHADI, F.. (2008). BLOOD ANTIOXIDANT LEVELS AND ALTERATIONS OF SERUM CALCIUM AND PH IN HEMODIALYSIS PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(1), 12-17. SID. https://sid.ir/paper/38583/en

Vancouver: Copy

HEMATI MAHDI, KADKHODAEI MEHRI, ZAHMATKESH M., MAHDAVI MAZDEH M., GHAZNAVI R., MIRERSHADI F.. BLOOD ANTIOXIDANT LEVELS AND ALTERATIONS OF SERUM CALCIUM AND PH IN HEMODIALYSIS PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(1):12-17. Available from: https://sid.ir/paper/38583/en

IEEE: Copy

MAHDI HEMATI, MEHRI KADKHODAEI, M. ZAHMATKESH, M. MAHDAVI MAZDEH, R. GHAZNAVI, and F. MIRERSHADI, “BLOOD ANTIOXIDANT LEVELS AND ALTERATIONS OF SERUM CALCIUM AND PH IN HEMODIALYSIS PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 1, pp. 12–17, 2008, [Online]. Available: https://sid.ir/paper/38583/en

Related Journal Papers