MOLECULAR EPIDEMIOLOGY OF HUMAN RESPIRATORY SYNCYTIAL VIRUS IN IRANIAN CHILDREN LESS THAN 5 YEARS IN 2007: A STUDY ON 72 CASES

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FAGHIHLOO EBRAHIM; REZAIE FARHAD; SALIMI VAHID; NASERI MARYAM; MAMISHI SETARE; MAHMOODI MAHMOOD; MOKHTARI AZAD TALAT

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Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:3 Page(s): 194-198

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Title

MOLECULAR EPIDEMIOLOGY OF HUMAN RESPIRATORY SYNCYTIAL VIRUS IN IRANIAN CHILDREN LESS THAN 5 YEARS IN 2007: A STUDY ON 72 CASES

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Keywords

HUMAN RESPIRATORY SYNCYTIAL VIRUSQ3

MOLECULAR EPIDEMIOLOGYQ2

CHILDRENQ3

IRANQ2

Abstract

Background: HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) is the most important viral agent of acute lower respiratory tract disease in infants and young CHILDREN worldwide. This virus is responsible for 50% brochiolitis and 25% pneumonia in infants. There are limited data of MOLECULAR EPIDEMIOLOGY of HRSV from developing countries. This is the report on the MOLECULAR EPIDEMIOLOGY of HUMAN RESPIRATORY SYNCYTIAL VIRUS in IRAN.Methods: In this study, RT-PCR for second hypervariable region of the HRSV G glycoprotein was performed on 72 throat swabs collected from CHILDREN less than 5 years of age with acute respiratory symptoms in 1386.Results: Of the 72 throat swabs collected from CHILDREN with acute respiratory symptoms, 14 (19.44%) were positive for HRSV. Phylogenetic analysis revealed that all HRSV-positive samples clustered in three genotypes of subgroup A: 12 strains (85/71%) in genotype GA2, 1 strain (7/1%) in genotype GA1, and 1 strain (7/1%) in genotype GA5. In this study we couldn’t identify any genotype of subgroup B.Conclusion: Our results revealed that multiple genotypes of subgroup A were cocirculated during 1386 in CHILDREN less than 5 years of age in IRAN. Also this study revealed that genotype GA2 was predominant genotype in isolates were obtained from several cities (Tehran, Isfahan, Karaj, Qazvin, Bandar Abbas, Shahreza), so we speculate that this genotype may be predominant during 1386 in IRAN. This study supported that RT-PCR for second variable region of G protein is an effective method for further studies of HRSV genotype designation in IRAN.

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APA: Copy

FAGHIHLOO, EBRAHIM, REZAIE, FARHAD, SALIMI, VAHID, NASERI, MARYAM, MAMISHI, SETARE, MAHMOODI, MAHMOOD, & MOKHTARI AZAD, TALAT. (2010). MOLECULAR EPIDEMIOLOGY OF HUMAN RESPIRATORY SYNCYTIAL VIRUS IN IRANIAN CHILDREN LESS THAN 5 YEARS IN 2007: A STUDY ON 72 CASES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(3), 194-198. SID. https://sid.ir/paper/38711/en

Vancouver: Copy

FAGHIHLOO EBRAHIM, REZAIE FARHAD, SALIMI VAHID, NASERI MARYAM, MAMISHI SETARE, MAHMOODI MAHMOOD, MOKHTARI AZAD TALAT. MOLECULAR EPIDEMIOLOGY OF HUMAN RESPIRATORY SYNCYTIAL VIRUS IN IRANIAN CHILDREN LESS THAN 5 YEARS IN 2007: A STUDY ON 72 CASES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(3):194-198. Available from: https://sid.ir/paper/38711/en

IEEE: Copy

EBRAHIM FAGHIHLOO, FARHAD REZAIE, VAHID SALIMI, MARYAM NASERI, SETARE MAMISHI, MAHMOOD MAHMOODI, and TALAT MOKHTARI AZAD, “MOLECULAR EPIDEMIOLOGY OF HUMAN RESPIRATORY SYNCYTIAL VIRUS IN IRANIAN CHILDREN LESS THAN 5 YEARS IN 2007: A STUDY ON 72 CASES,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 3, pp. 194–198, 2010, [Online]. Available: https://sid.ir/paper/38711/en

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