EFFECT OF DIMETHYL SULFOXIDE ON INJURIES AND NEUROLOGICAL DEFICITS: A RAT MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAKILI ABEDIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2008 | Volume:66 | Issue:8 Page(s): 538-544

Download Full-Text

Persian Verion

View:

1,182

Download:

Cites:

Information Journal Paper

Title

EFFECT OF DIMETHYL SULFOXIDE ON INJURIES AND NEUROLOGICAL DEFICITS: A RAT MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA

Author(s)

VAKILI ABEDIN | Issue Writer Certificate

Keywords

DIMETHYL SULFOXIDEQ3

CEREBRALQ3

ISCHEMIAQ3

TRANSIENTQ3

FOCALQ3

RATQ3

Abstract

Background: DIMETHYL SULFOXIDE (DMSO) has been used as a solvent for many drugs in ischemic experiments. DMSO has many biological benefits, including antioxidant, antiinflammatory, platelet aggregation inhibiting and cell membrane stabilizing effects. Moreover, some experimental studies report that DMSO has a neurprotective effect in permanent FOCAL CEREBRAL ISCHEMIA. Despite the effect of DMSO on the cortex, striatum injuries and motor neurological dysfunctions in TRANSIENT FOCAL CEREBRAL ISCHEMIA are not completely clear.Methods: Thirty-six male Sprague-Dawley RATs weighing 300-350 g were divided into saline- (control) and DMSO-treated groups. Under chloral hydrate anesthesia (400mg/kg, ip), TRANSIENT FOCAL CEREBRAL ISCHEMIA was induced by 90-min middle CEREBRAL artery occlusion (MCAO) followed by 23-h reperfusion. RATs received saline (n=11) or 2% DMSO intraperitoneally at doses of 0.01 (n=11), 0.1 (n=7) and 0.2 (n=7) ml/kg 30 min prior to induction of ISCHEMIA. Twenty-four hours after MCAO, the neurological deficit scores were ascertained. Cortical and striatal infarct volumes determined by triphenyltetrazolium chloride staining. Results: Administration of DMSO at doses of 0.1 and 0.2 ml/kg significantly reduced cortical and striatal infarct volumes (p<0.001), while RATs receiving the 0.1 ml/kg dose had infarct volumes similar to those of the control group (p=0.225). Moreover, only 0.2 ml/kg doses of DMSO significantly reduce neurological motor dysfunction (p<0.001). Conclusions: Findings of this study indicate that DMSO is a potent neuroprotective agent against TRANSIENT FOCAL CEREBRAL ISCHEMIA in RAT. Moreover, our data also suggest that DMSO may be a candidate for acute stroke treatment.

Cites

No record.

References

No record.

Cite

APA: Copy

VAKILI, ABEDIN. (2008). EFFECT OF DIMETHYL SULFOXIDE ON INJURIES AND NEUROLOGICAL DEFICITS: A RAT MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(8), 538-544. SID. https://sid.ir/paper/38774/en

Vancouver: Copy

VAKILI ABEDIN. EFFECT OF DIMETHYL SULFOXIDE ON INJURIES AND NEUROLOGICAL DEFICITS: A RAT MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(8):538-544. Available from: https://sid.ir/paper/38774/en

IEEE: Copy

ABEDIN VAKILI, “EFFECT OF DIMETHYL SULFOXIDE ON INJURIES AND NEUROLOGICAL DEFICITS: A RAT MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 8, pp. 538–544, 2008, [Online]. Available: https://sid.ir/paper/38774/en

Related Journal Papers