CLINICAL CHARACTERISTIC AND OUTCOME OF PEDIATRIC GERM CELL TUMORS IN ALI-ASGHAR CHILDREN'S HOSPITAL; 1990-2004

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ANSARI SH.; VOSOUGH PARVANEH; TABAROKI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Tehran University Medical Journal Year:2007 | Volume:64 | Issue:11 Page(s): 65-68

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Title

CLINICAL CHARACTERISTIC AND OUTCOME OF PEDIATRIC GERM CELL TUMORS IN ALI-ASGHAR CHILDREN'S HOSPITAL; 1990-2004

Author(s)

ANSARI SH. | VOSOUGH PARVANEH | TABAROKI A. | Issue Writer Certificate

Keywords

GERM CELL- TERATOMAQ3

DYSGERMINOMAQ3

CHEMOTHERAPYQ3

ALPHA FETO PROTEINQ3

Abstract

Background: Germ cell tumor (GCT) account for approximately 2-3% of all malignancies in childhood. About 20% of patients with GCT are still resistant to therapy.Methods: This study was undertaken on 57 patients with Germ cell tumor who were admitted to Ali Asghar Children's Hospital during 1990-2004. Through this study, information about sex, age type of pathology, clinical sign, treatment and survival (5-year period) was gathered in order to have better treatment and follow up. This study was carried out as across-sectional survey and the obtained data was analyzed via Spss 10 soft ware. Results: The findings showed that the mean age of patients was 4/9±0/1 (1mo -14y), male 54%, female 46%, male/female, ratio=1/1. Site of tumor: saccrococcygeal 57/8 %( 33), gonadal 42% (24). Pathological type is yolk sac 61/4% (35), DYSGERMINOMA 12/2% (7), malignant teratoma 14% (8), embryonal carcinoma 10/5% (6). The most common clinical sign were buttockmass 31/5% (18), abdominal pain 10/5% (6), abdominal mass 17/5%(10), testicular mass 28% (16). All of the patients were treated with CHEMOTHERAPY (bleomycine, vinblastin, cisplatinum) mean of duration follow up were 48/4 months. In all of patients 31/5% (18) of the cases were alive and 70% (40) of patients were relapse and 15/7% (9) no information, 52/6% (30) of cases were expired. Five years survival of patients was 62%.Conclusion: The analysis of the patients treated shows that extragonadal location of primary tumor (specially sacrococcygeal), level of AFP above 10 ng/ml in patients ,6 or more months of age and metastatic disease were the most unfavorable factors for overall survival.

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APA: Copy

ANSARI, SH., VOSOUGH, PARVANEH, & TABAROKI, A.. (2007). CLINICAL CHARACTERISTIC AND OUTCOME OF PEDIATRIC GERM CELL TUMORS IN ALI-ASGHAR CHILDREN'S HOSPITAL; 1990-2004. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(11), 65-68. SID. https://sid.ir/paper/38798/en

Vancouver: Copy

ANSARI SH., VOSOUGH PARVANEH, TABAROKI A.. CLINICAL CHARACTERISTIC AND OUTCOME OF PEDIATRIC GERM CELL TUMORS IN ALI-ASGHAR CHILDREN'S HOSPITAL; 1990-2004. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;64(11):65-68. Available from: https://sid.ir/paper/38798/en

IEEE: Copy

SH. ANSARI, PARVANEH VOSOUGH, and A. TABAROKI, “CLINICAL CHARACTERISTIC AND OUTCOME OF PEDIATRIC GERM CELL TUMORS IN ALI-ASGHAR CHILDREN'S HOSPITAL; 1990-2004,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 11, pp. 65–68, 2007, [Online]. Available: https://sid.ir/paper/38798/en

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