THE COMPARISON BETWEEN MONOTHERAPY AND COMBINATION THERAPY IN RHEUMATOID ARTHRITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHALVAT A.; ROSTAMIAN A.A.R.; NAJFIZADEH S.R.; MEYSAMI A.P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2007 | Volume:64 | Issue:11 Page(s): 69-76

Download Full-Text

Persian Verion

View:

2,361

Download:

Cites:

Information Journal Paper

Title

THE COMPARISON BETWEEN MONOTHERAPY AND COMBINATION THERAPY IN RHEUMATOID ARTHRITIS

Author(s)

KHALVAT A. | ROSTAMIAN A.A.R. | NAJFIZADEH S.R. | MEYSAMI A.P. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ3

HYDROXY CHLOROQUINQ3

METHOTREXATEQ3

SULFASALAZINQ4

COMBINATION THERAPYQ3

Abstract

Background: RHEUMATOID ARTHRITIS (RA)is a chronic inflammatory condition. The condition can affected many tissues throught out the body, but the joints are usually most severely affected. The high incidence of RA, the conventional treatments and the experimental observation have shown by COMBINATION THERAPY, the disease symptoms of the patients reduce. To compare the efficacy and tolerability of single-agent Hydroxychloroquin (HCQ) with combination therapies composed of (HCQ) and METHOTREXATE (MIX) and (HCQ),(MIX) and SULFASALAZIN (ssz) in active RHEUMATOID ARTHRITIS patients with additive arthritis. Methods: One hundred and twenty RA patients with active arthritis (male/female: 30/90) who were treated in rheumatology clinic between 2003 and 2005 were emolled in this trial. Patients treated with (HCQ) alone (200 mg/day)were include in group (I), patients treated with combination of (HCQ) (200 mglday)and (MIX) (7.5mglweek)in group (n),and patents treated with combination of (HCQ) (200 mg/day),(MIX) (7.5mglweek)and (ssz) (1 gr/day)in group (m), Forty patients (male/female:10/30) in group (I),(n) and (m)were eligible for statistical analysis at the end of study. Changes in variable were compared by the T-test.Results: The combination of (MTX),(HcQ) and (ssz) and the combination of (MIX) and (HCQ)were more effective regarding the clinical and laboratory parameters than (HCQ) alone (P<0.05). Moreover the combination of (MIX), (HCQ) and (ssz) was more effective than the combination of (MIX) and (HCQ) (P<0.05). Combination therapies seem to be more effective and no more toxic than monotherapy in RA patients with additive arthritis. Conclusion: COMBINATION THERAPY with METHOTREXATE, hydroxychloroquin and SULFASALAZIN is more effective than hydroxychloroquin alone or a combination of METHOTREXATE and hydroxychloroquin in RA. We suggest starting COMBINATION THERAPY for the patients with early RA, when the diagnosis has been established.

Cites

No record.

References

No record.

Cite

APA: Copy

KHALVAT, A., ROSTAMIAN, A.A.R., NAJFIZADEH, S.R., & MEYSAMI, A.P.. (2007). THE COMPARISON BETWEEN MONOTHERAPY AND COMBINATION THERAPY IN RHEUMATOID ARTHRITIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(11), 69-76. SID. https://sid.ir/paper/38804/en

Vancouver: Copy

KHALVAT A., ROSTAMIAN A.A.R., NAJFIZADEH S.R., MEYSAMI A.P.. THE COMPARISON BETWEEN MONOTHERAPY AND COMBINATION THERAPY IN RHEUMATOID ARTHRITIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;64(11):69-76. Available from: https://sid.ir/paper/38804/en

IEEE: Copy

A. KHALVAT, A.A.R. ROSTAMIAN, S.R. NAJFIZADEH, and A.P. MEYSAMI, “THE COMPARISON BETWEEN MONOTHERAPY AND COMBINATION THERAPY IN RHEUMATOID ARTHRITIS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 11, pp. 69–76, 2007, [Online]. Available: https://sid.ir/paper/38804/en

Related Journal Papers