Role of autophagy associated with Helicobacter pylori CagA and VacA toxins in gastric cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YOUSEFI BAHMAN; ESLAMI MAJID; KOKHAEI PARVIZ; VALIZADEH SAEID; GHASEMIAN ABDOLMAJID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2019 | Volume:21 | Issue:2 (74) Page(s): 205-214

Download Full-Text

Persian Verion

View:

762

Download:

Cites:

Information Journal Paper

Title

Role of autophagy associated with Helicobacter pylori CagA and VacA toxins in gastric cancer

Author(s)

Keywords

AutophagyQ1

Gastric CancerQ2

Helicobacter PyloriQ2

Bacterial AntigensQ1

Bacterial ProteinsQ1

Abstract

Helicobacter Pylori (H. pylori) is a gram-negative microaerophilic bacterium that has been introduced as a cause of mucosal inflammation and Gastric Cancer. The most important pathogenic factors are VacA and CagA, which are associated with increased disease severity in clinical strains. Autophagy is a protected lysosomal degradation pathway degrading cytoplasmic content and is important in host cell defense, survival, differentiation and development. It can have a tumor suppressor activity or cancer progression and plays an important role in host safety and homeostatic. H. pylori can affect host pathogenic pathway through VacA and CagA virulence factors and carcinogenesis. Increasing Autophagy in tumor cells prevents the accumulation of non-functional mitochondria that can disrupt tumorigenicity. The ability of H. pylori to manipulate host pathogenesis pathway is considered as one of the important aspects of its pathogenesis. Several studies have shown that infection with H. pylori causes Autophagy in both gastric epithelial cells and phagocytes. In the epithelial cells of the stomach, VacA is a necessary factor in Autophagy. While CagA is a negative regulator of the phenomenon, the elimination of this gene from H. pylori has increased Autophagy and the production of inflammatory cytokines is reduced.

Cites

No record.

References

No record.

Cite

APA: Copy

YOUSEFI, BAHMAN, ESLAMI, MAJID, KOKHAEI, PARVIZ, VALIZADEH, SAEID, & GHASEMIAN, ABDOLMAJID. (2019). Role of autophagy associated with Helicobacter pylori CagA and VacA toxins in gastric cancer. KOOMESH, 21(2 (74) ), 205-214. SID. https://sid.ir/paper/389143/en

Vancouver: Copy

YOUSEFI BAHMAN, ESLAMI MAJID, KOKHAEI PARVIZ, VALIZADEH SAEID, GHASEMIAN ABDOLMAJID. Role of autophagy associated with Helicobacter pylori CagA and VacA toxins in gastric cancer. KOOMESH[Internet]. 2019;21(2 (74) ):205-214. Available from: https://sid.ir/paper/389143/en

IEEE: Copy

BAHMAN YOUSEFI, MAJID ESLAMI, PARVIZ KOKHAEI, SAEID VALIZADEH, and ABDOLMAJID GHASEMIAN, “Role of autophagy associated with Helicobacter pylori CagA and VacA toxins in gastric cancer,” KOOMESH, vol. 21, no. 2 (74) , pp. 205–214, 2019, [Online]. Available: https://sid.ir/paper/389143/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops