Effects of oral gavage treatment of Eupatilin on protection of skin flaps in rats

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MIRZAY RAZAZ JALALEDIN; EBADI FARDAZAR AMIR ALI; NAZIRI MAHDYIEH; BANIMOHAMMAD MAJID; Majdi Seghinsara Abbas; Javdan Gholamali

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Journal: Koomesh Year:2019 | Volume:21 | Issue:2 (74) Page(s): 318-323

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Title

Effects of oral gavage treatment of Eupatilin on protection of skin flaps in rats

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Keywords

EupatilinQ1

Skin flapQ1

tissue necrosisQ1

Malondialdehyde (MDA)Q1

Superoxide dismutase (SOD)Q1

Abstract

Introduction: Nowadays, Skin flaps are used to repair wounds, skin lesions and in reconstructive surgeries. In this way, the main problem is loss of flap tissue and necrosis, due to processes that result from ischemia-reperfusion injury and reactive oxygen species. Eupatilin is an O-methylated flavone derived from Artemisia plants that demonstrates anti-inflammatory, anti-oxidative, and anti-tumor effects. In this study, we evaluated the effect of Eupatilin administration on the survival of Skin flap and oxidative stress by measuring necrotic area of Skin flap and oxidative stress markers, in rats. Materials and Methods: Forty rats were divided into four groups (10 rats per group), including Sham group, Flap group, Eupatilin+ Flap group (received Eupatilin before flap), and Flap + Eupatilin group (received Eupatilin after flap). Eupatilin (10 mg / kg) was administered as oral gavage to mice. One week after flap surgery in a 3 x 8 cm scale, flap necrosis, malondialdehyde (MDA) levels-using thiobarbituric acid method (TBA)-and superoxide dismutase (SOD)-using an oxidase enzymatic method-was measured. Results: Treatment with Eupatilin, before or after flap, reduced the necrosis area of flap (P <0. 05 vs flap group). Decreased MDA level (P <0. 05 vs flap group) and increased superoxide dismutase activity (SOD) (P <0. 01 vs flap group) are shown. Conclusion: The data obtained from this study demonstrated improvement of Skin flap survival in rats and reduction of tissue necrosis and oxidative stress by Eupatilin treatment, either before or after flap surgery.

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APA: Copy

MIRZAY RAZAZ, JALALEDIN, EBADI FARDAZAR, AMIR ALI, NAZIRI, MAHDYIEH, BANIMOHAMMAD, MAJID, Majdi Seghinsara, Abbas, & Javdan, Gholamali. (2019). Effects of oral gavage treatment of Eupatilin on protection of skin flaps in rats. KOOMESH, 21(2 (74) ), 318-323. SID. https://sid.ir/paper/389640/en

Vancouver: Copy

MIRZAY RAZAZ JALALEDIN, EBADI FARDAZAR AMIR ALI, NAZIRI MAHDYIEH, BANIMOHAMMAD MAJID, Majdi Seghinsara Abbas, Javdan Gholamali. Effects of oral gavage treatment of Eupatilin on protection of skin flaps in rats. KOOMESH[Internet]. 2019;21(2 (74) ):318-323. Available from: https://sid.ir/paper/389640/en

IEEE: Copy

JALALEDIN MIRZAY RAZAZ, AMIR ALI EBADI FARDAZAR, MAHDYIEH NAZIRI, MAJID BANIMOHAMMAD, Abbas Majdi Seghinsara, and Gholamali Javdan, “Effects of oral gavage treatment of Eupatilin on protection of skin flaps in rats,” KOOMESH, vol. 21, no. 2 (74) , pp. 318–323, 2019, [Online]. Available: https://sid.ir/paper/389640/en

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