EFFECT OF MICROALBUMINURIA-LOWERING ON REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL HYPERTENSION

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ASADI F.; AKBARI ASBAGH PARVIN; HAJIZADEH NILOUFAR

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Journal: Tehran University Medical Journal Year:2007 | Volume:64 | Issue:10 Page(s): 1-5

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Title

EFFECT OF MICROALBUMINURIA-LOWERING ON REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL HYPERTENSION

Author(s)

ASADI F. | AKBARI ASBAGH PARVIN | HAJIZADEH NILOUFAR | Issue Writer Certificate

Keywords

MICROALBUMINURIAQ3

HYPERTENSIONQ3

LEFT VENTRICULAR HYPERTROPHYQ3

Abstract

Background: MICROALBUMINURIA (MA) is associated with increased cardiovascular risk in hypertensive patients, but not many studies have specifically examined the effects of MA-lowering on regression of LEFT VENTRICULAR HYPERTROPHY (LVH) among pediatric patients with HYPERTENSION.Methods: Fifty-five patients with essential HYPERTENSION, 11 to 19 years old were prospectively studied. All patients received concomitant therapy of hydrochlorothiazide and angiotensin- converting-enzyme inhibitor. Five patients also required angiotensin- receptor blocker to achieve the blood pressure goal. Baseline and 12-month follow-up measures of left ventricular mass index (LVMI) determined by echocardiography and urine microalbumin/ creatinine ratio (MA/Cr) were collected. MA was defined as MA/Cr>30. LVH was defined as LVMI>38.6 g/m2. The primary end points were 25% or more reductions in MA and the LVMI.Results: Weight (r=0.83), body surface area (r=0.85), body mass index (BMI) (r=0.86), systolic blood pressure (SBP) (r=0.57), diastolic blood pressure (DBP) (r=0.49), mean arterial pressure (r=0.53) and MA (r=0.87) were all univariate correlates of LVMI. In a multiple regression analysis, MA, BMI and SBP were significant correlates of LVMI. MA alone explained 76% of the variance of LVMI, whereas BMI and SBP explained only 1.6% and 0.4% of the variance, respectively. MA was the most significant correlate of follow-up LVMI after BMI and SBP were included in the overall multiple regression models.Conclusion: MA is a strong predictor of LVH in hypertensive children and adolescents. MA-lowering halts the progression of LVH or induces its regression.

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APA: Copy

ASADI, F., AKBARI ASBAGH, PARVIN, & HAJIZADEH, NILOUFAR. (2007). EFFECT OF MICROALBUMINURIA-LOWERING ON REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL HYPERTENSION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(10), 1-5. SID. https://sid.ir/paper/38965/en

Vancouver: Copy

ASADI F., AKBARI ASBAGH PARVIN, HAJIZADEH NILOUFAR. EFFECT OF MICROALBUMINURIA-LOWERING ON REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL HYPERTENSION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;64(10):1-5. Available from: https://sid.ir/paper/38965/en

IEEE: Copy

F. ASADI, PARVIN AKBARI ASBAGH, and NILOUFAR HAJIZADEH, “EFFECT OF MICROALBUMINURIA-LOWERING ON REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL HYPERTENSION,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 10, pp. 1–5, 2007, [Online]. Available: https://sid.ir/paper/38965/en

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