The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Soltanian Alale; MOSALLANEJAD BAHMAN; RAZI JALALI MOHAMMAD; NAJAFZADEH VARZI HOSSEIN; Ghorbanpour Najafabadi Masoud

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Veterinary Medicine Year:2019 | Volume:13 | Issue:4 Page(s): 377-387

Download Full-Text

Persian Verion

View:

207

Download:

106

Cites:

Information Journal Paper

Title

The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone

Author(s)

Keywords

DogQ2

hydrocortisoneQ1

lipopolysaccharideQ1

quercetinQ1

sepsisQ1

Abstract

BACKGROUND: Canine low-dose sepsis model provides a reliable setting to study innovative drugs. lipopolysaccharides (LPS), a major constituent of bacterial outer membrane, have been demonstrated to play a critical role in the initiation of pathogenesis. lipopolysaccharide-induced sepsis has been extensively studied in laboratory animals; but its importance has mainly remained unknown in Dogs. OBJECTIVES: The aim of the present survey was to examine the effectiveness of quercetin, along with hydrocortisone on clinical and hematological alterations, and organ failure (liver and heart) in low-dose lipopolysaccharide-induced canine sepsis model. METHODS: For this purpose, fifteen clinically healthy mixed Dogs were randomly divided into three equal groups. lipopolysaccharide (0. 1 μ g/kg, IV) was injected to Dogs in group A (control). Group B was similar to group A, but quercetin bolus (2 mg/kg, IV, once) was injected 40 minutes after LPS injection. Group C was similar to group B; however, hydrocortisone bolus (2 mg/kg, IV, once) was administered instead of quercetin. Serum levels of glucose, total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatine kinase isoenzyme muscle/brain (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin I (cTn-I) concentration were measured by commercial kits. RESULTS: In control group, red blood cells (RBCs), hemoglobin (Hb), and hematocrit (HCT) significantly decreased and serum activities of AST, ALP, LDH, CK-MB, and plasma cTn-I significantly increased (P<0. 05). RBCs, Hb, and HCT significantly increased in quercetin group, compared with hydrocortisone and control groups (P<0. 05). quercetin group significantly decreased LDH, CK-MB, and cTn-I compared with hydrocortisone and control groups (P<0. 05). quercetin significantly decreased AST in comparison to control group and ALP in comparison to hydrocortisone group, also (P<0. 05). CONCLUSIONS: These results suggest that quercetin protects RBCs in the early stages of sepsis and decreases organs dysfunction (heart and liver), therefore it has a positive influence on sepsis and may be more effective than routine corticosteroid (hydrocortisone) therapy.

Cites

No record.

References

No record.

Cite

APA: Copy

Soltanian, Alale, MOSALLANEJAD, BAHMAN, RAZI JALALI, MOHAMMAD, NAJAFZADEH VARZI, HOSSEIN, & Ghorbanpour Najafabadi, Masoud. (2019). The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 13(4 ), 377-387. SID. https://sid.ir/paper/389874/en

Vancouver: Copy

Soltanian Alale, MOSALLANEJAD BAHMAN, RAZI JALALI MOHAMMAD, NAJAFZADEH VARZI HOSSEIN, Ghorbanpour Najafabadi Masoud. The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2019;13(4 ):377-387. Available from: https://sid.ir/paper/389874/en

IEEE: Copy

Alale Soltanian, BAHMAN MOSALLANEJAD, MOHAMMAD RAZI JALALI, HOSSEIN NAJAFZADEH VARZI, and Masoud Ghorbanpour Najafabadi, “The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 13, no. 4 , pp. 377–387, 2019, [Online]. Available: https://sid.ir/paper/389874/en

Related Journal Papers