CARDIOVASCULAR COMPLICATIONS OF THALASSEMIA MAJOR AND THALASSEMIA INTERMEDIA

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COMPANI F.; REZAEI NAZILA; MOZAFARI R.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:13 | Issue:2 (SERIAL NUMBER 48) Page(s): 1-9

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Title

CARDIOVASCULAR COMPLICATIONS OF THALASSEMIA MAJOR AND THALASSEMIA INTERMEDIA

Author(s)

COMPANI F. | REZAEI NAZILA | MOZAFARI R. | Issue Writer Certificate

Keywords

THALLASEMIAQ3

ECHOCARDIOGRAPHYQ3

SERUM FERRITINQ3

CARDIAC COMPLICATIONQ3

PULMONARY HYPERTENSIONQ2

Abstract

Background and Aim: CARDIAC COMPLICATIONs due to Iron overload are the most common cause of death in B-thalassemicpatients. Although regular blood transfusions in thalassemia major(TM) patients have improved the quality oflife of the patients but the most important complication of such transfusions is iron overload in cardiac tissues. In spite of iron overload in untransfused thalassemia intermedia (TI) patients, the intestinal absorption of iron increases in these patients because of ineffective erythropoesis. The aim of this study was to evaluate cardiac status in thalassemia major and intermedia patients and the investigation of the possible effect of iron overload in the heart of B-thalassemicpatients.Material and Methods: 46 patients entered into this study. 26 patients had thalassemia major with regular blood and also chelator transfusions and 20 patients with thalassemia intermedia who had not received regular transfusions. The age' of the patients in the 2 groups were similar. The results of clinical evaluation and echocardiographies of the patients of the 2 groups were compared with each other. Collected data were analyzed by means of X2 and man whitney U tests.Results: Heart failure occurred in two patients with TM (9.52%) and one patient with TI (4.76%). Considerable PULMONARY HYPERTENSION (systolic tricuspid gradien~ >35mmHg) was only present in 3 patients with TI (14.28%). But systolic dysfunction of left ventricle (ejection ftaction<55% or shortening ftaction<35%) occurred in 5 patients with TM (23.8%). In the patients without apparent heart disease, cardiac dimensions, LV mass, LV shortening and ejection ftactions, cardiac output and valvular involvement were significantly more in patients with TI. But the maximum speed of systolic flow out of mitral valve in primary phase was higher significantly in TM patients than TI patients.Conclusion: Regular lifelong transfusion and chelation therapy in TM patients prevents premature heart disease and PULMONARY HYPERTENSION, but LV dysfunction can occur and lead to heart failure. In contrast in TI patients left ventricular function is normal but PULMONARY HYPERTENSION occurs which may lead to heart failure. Left ventricular performance is better preserved when chelation treatment is adjusted to maintain the SERUM FERRITIN concentration at <1000 nglml.

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APA: Copy

COMPANI, F., REZAEI, NAZILA, & MOZAFARI, R.. (2008). CARDIOVASCULAR COMPLICATIONS OF THALASSEMIA MAJOR AND THALASSEMIA INTERMEDIA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 13(2 (SERIAL NUMBER 48)), 1-9. SID. https://sid.ir/paper/390983/en

Vancouver: Copy

COMPANI F., REZAEI NAZILA, MOZAFARI R.. CARDIOVASCULAR COMPLICATIONS OF THALASSEMIA MAJOR AND THALASSEMIA INTERMEDIA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;13(2 (SERIAL NUMBER 48)):1-9. Available from: https://sid.ir/paper/390983/en

IEEE: Copy

F. COMPANI, NAZILA REZAEI, and R. MOZAFARI, “CARDIOVASCULAR COMPLICATIONS OF THALASSEMIA MAJOR AND THALASSEMIA INTERMEDIA,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 2 (SERIAL NUMBER 48), pp. 1–9, 2008, [Online]. Available: https://sid.ir/paper/390983/en

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