DRUG SUSCEPTIBILITY PATTERN OF CANDIDA SPECIES ISOLATED FROM SKIN OF NEONATES TO FLUCONAZOLE, AMPHOTERICIN B AND CASPOFUNGIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHORBANI SORAYA; DAIE GHAZVINI ROSHANAK; HASHEMI SEYYED JAMAL; KORDBACHEH PARIVASH; ZIBAFAR ENSIEH; Kamali sarwestani Zahra; Bakhshi Heidar; ARDI PEGAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2017 | Volume:75 | Issue:4 Page(s): 267-272

Download Full-Text

Persian Verion

View:

1,227

Download:

Cites:

Information Journal Paper

Title

DRUG SUSCEPTIBILITY PATTERN OF CANDIDA SPECIES ISOLATED FROM SKIN OF NEONATES TO FLUCONAZOLE, AMPHOTERICIN B AND CASPOFUNGIN

Author(s)

Keywords

AMPHOTERICIN BQ2

CANDIDAQ2

CASPOFUNGINQ2

DRUG SUSCEPTIBILITYQ2

NEONATESQ1

FLUCONAZOLEQ3

Abstract

Background: CANDIDA species are opportunistic yeasts that are capable of causing different infections and diseases among immunocompromised patients. Since CANDIDA infections are major causes and frequent of septicemia in Neonatal Intensive Care Units (NICU), and they are associated with high morbidity and mortality rates, so obtaining adequate treatment seems necessary. Low birth weight preterm infants are especially vulnerable to these devastating infections. The aim of this study was to evaluate the DRUG SUSCEPTIBILITY of CANDIDA species colonized on the skin and mucous membrane of NEONATES to FLUCONAZOLE, AMPHOTERICIN B and CASPOFUNGIN.Methods: This study was carried out in the laboratory of medical mycology and serology, School of Public Health, Tehran University of Medical Sciences for the period of 7 months from June 2016 to December 2016. In this descriptive crosssectional study, 23 isolates of CANDIDA species includingCandida parapsilosis, CANDIDA albicans, CANDIDA tropicalis, CANDIDA guilliermondiiand CANDIDA krusei were studied. These under study isolates were previously isolated from skin and mucous membranes of NEONATES in NICU of Imam Khomeini Hospital and Children' s Medical Center were identified by PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism). Evaluation of antifungal DRUG SUSCEPTIBILITY including FLUCONAZOLE, AMPHOTERICIN B and CASPOFUNGIN was carried out. Antifungal susceptibility test was done according to the standard protocol Clinical and Laboratory Standards Institute (CLSI M27-A3) that is specific to the yeast fungi. Statistical analysis was done by using T-test in SPSS version 22 (IBM, Armonk, NY, USA) and P<0.05 was considered statistically significant.Results: In this study, C. parapsilosis, C. albicans and C. tropicalis had the most sensitivity to FLUCONAZOLE. Clinical Isolates of C. guilliermondii were also sensitive to FLUCONAZOLE, but in C. krusei sensitivity was dose-dependent. All isolated species were sensitive to AMPHOTERICIN B and CASPOFUNGIN.Conclusion: According to the results, all isolated CANDIDA species were more sensitive to AMPHOTERICIN B and CASPOFUNGIN than other antifungal drugs. In final conclusion, Finally, it is emphasized that antifungal susceptibility testing is necessary to prevent treatment failure or recurrence of disease.

Cites

No record.

References

Cite

APA: Copy

GHORBANI, SORAYA, DAIE GHAZVINI, ROSHANAK, HASHEMI, SEYYED JAMAL, KORDBACHEH, PARIVASH, ZIBAFAR, ENSIEH, Kamali sarwestani, Zahra, Bakhshi, Heidar, & ARDI, PEGAH. (2017). DRUG SUSCEPTIBILITY PATTERN OF CANDIDA SPECIES ISOLATED FROM SKIN OF NEONATES TO FLUCONAZOLE, AMPHOTERICIN B AND CASPOFUNGIN. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 75(4), 267-272. SID. https://sid.ir/paper/39139/en

Vancouver: Copy

GHORBANI SORAYA, DAIE GHAZVINI ROSHANAK, HASHEMI SEYYED JAMAL, KORDBACHEH PARIVASH, ZIBAFAR ENSIEH, Kamali sarwestani Zahra, Bakhshi Heidar, ARDI PEGAH. DRUG SUSCEPTIBILITY PATTERN OF CANDIDA SPECIES ISOLATED FROM SKIN OF NEONATES TO FLUCONAZOLE, AMPHOTERICIN B AND CASPOFUNGIN. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2017;75(4):267-272. Available from: https://sid.ir/paper/39139/en

IEEE: Copy

SORAYA GHORBANI, ROSHANAK DAIE GHAZVINI, SEYYED JAMAL HASHEMI, PARIVASH KORDBACHEH, ENSIEH ZIBAFAR, Zahra Kamali sarwestani, Heidar Bakhshi, and PEGAH ARDI, “DRUG SUSCEPTIBILITY PATTERN OF CANDIDA SPECIES ISOLATED FROM SKIN OF NEONATES TO FLUCONAZOLE, AMPHOTERICIN B AND CASPOFUNGIN,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 75, no. 4, pp. 267–272, 2017, [Online]. Available: https://sid.ir/paper/39139/en

Related Journal Papers