THE EFFECT OF INTRATHECAL ADMINISTRATION OF GAP JUNCTION BLOCKER AND GABAA AGONIST AND/OR ANTAGONIST ON CHEMICAL PAIN BEHAVIORAL RESPONSES IN MALE RAT

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AFSHAR KARGAR SIMIN; FEREIDONI MASOUD; MAHDAVI SHAHRI NASER

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Journal: DANESHVAR MEDICINE Year:2013 | Volume:20 | Issue:105 Page(s): 1-10

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Title

THE EFFECT OF INTRATHECAL ADMINISTRATION OF GAP JUNCTION BLOCKER AND GABAA AGONIST AND/OR ANTAGONIST ON CHEMICAL PAIN BEHAVIORAL RESPONSES IN MALE RAT

Author(s)

AFSHAR KARGAR SIMIN | FEREIDONI MASOUD | MAHDAVI SHAHRI NASER | Issue Writer Certificate

Keywords

PAINQ2

INTRATHECAL INJECTIONQ2

GAP JUNCTIONSQ2

CARBENOXOLONEQ2

GABAAQ2

Abstract

Background and Objective: GABAergic inhibitory interneurons are distributed in spinal cord for PAIN sensation, so that muscimol and bicuculline (GABAA agonist and antagonist) reduces and enhances PAIN, respectively. GAP JUNCTIONS (Gj) are membrane contacts for exchanging the signaling agents and small metabolites. Using spinal administration (i.t) of CARBENOXOLONE (Gj blockers), this study tried to understand the Gj and spinal GABAergic system roles on chemical PAIN sensation.Materials ad Methods: Male Wistar rats (200-250 g) were divided into 8 groups (n=7). The drugs were injected at 10 ml volume intrathecally including CARBENOXOLONE (1nM), muscimol (0.3 mg) and bicuculline (0.3 and 0.6 mg) individually or as a form of co-treatment. Sub-plantar injection of 0.05 ml of 2.5% formalin was used and PAIN related behaviors were recorded for 1 hour.Results: CARBENOXOLONE and muscimol reduced PAIN (p<0.01 and p<0.05, respectively), and bicuculline elevated PAIN (p<0.01) induced by formalin. CARBENOXOLONE co-treatment with muscimol reduced PAIN more than each one (p<0.05). Administration of CARBENOXOLONE reduced hyperalgesia induced by bicuculline (p<0.05).Conclusion: Muscimol analgesic effect elevation and bicuculline hyperalgesic effect alleviation followed by Gjs blockade might be explained when the existence of Gj is considered between a primary inhibitory interneuron effective on a secondary interneuron which inhibits spinal PAIN projection neurons.

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APA: Copy

AFSHAR KARGAR, SIMIN, FEREIDONI, MASOUD, & MAHDAVI SHAHRI, NASER. (2013). THE EFFECT OF INTRATHECAL ADMINISTRATION OF GAP JUNCTION BLOCKER AND GABA_A AGONIST AND/OR ANTAGONIST ON CHEMICAL PAIN BEHAVIORAL RESPONSES IN MALE RAT. DANESHVAR MEDICINE, 20(105), 1-10. SID. https://sid.ir/paper/391483/en

Vancouver: Copy

AFSHAR KARGAR SIMIN, FEREIDONI MASOUD, MAHDAVI SHAHRI NASER. THE EFFECT OF INTRATHECAL ADMINISTRATION OF GAP JUNCTION BLOCKER AND GABA_A AGONIST AND/OR ANTAGONIST ON CHEMICAL PAIN BEHAVIORAL RESPONSES IN MALE RAT. DANESHVAR MEDICINE[Internet]. 2013;20(105):1-10. Available from: https://sid.ir/paper/391483/en

IEEE: Copy

SIMIN AFSHAR KARGAR, MASOUD FEREIDONI, and NASER MAHDAVI SHAHRI, “THE EFFECT OF INTRATHECAL ADMINISTRATION OF GAP JUNCTION BLOCKER AND GABA_A AGONIST AND/OR ANTAGONIST ON CHEMICAL PAIN BEHAVIORAL RESPONSES IN MALE RAT,” DANESHVAR MEDICINE, vol. 20, no. 105, pp. 1–10, 2013, [Online]. Available: https://sid.ir/paper/391483/en

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