THE EFFECT OF ECHINACEA PURPUREA AERIAL ORGAN DRIED EXTRACT VS. ZINC OXIDE ON SKIN WOUND HEALING IN RAT: A MORPHOMETRIC & HISTOPATHOLOGIC STUDY

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TAGHIZADEH JAHED M.; JAR ALMASJED S.H.; MOHAMMADNEZHAD SAMAD; REZAEI ALI; DELAZAR A.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2008 | Volume:66 | Issue:9 Page(s): 625-632

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Title

THE EFFECT OF ECHINACEA PURPUREA AERIAL ORGAN DRIED EXTRACT VS. ZINC OXIDE ON SKIN WOUND HEALING IN RAT: A MORPHOMETRIC & HISTOPATHOLOGIC STUDY

Author(s)

Keywords

ECHINACEA PURPUREAQ3

HERBAL EXTRACTQ4

RATQ3

SKIN WOUNDQ3

HEALINGQ2

Abstract

Background: Because of eventual side effects of chemical drugs, the efficacy of natural wound HEALING accelerators in long-term diseases and some situations is demanded to practitioners. The initial aim of our study was to assess full thickness excisional SKIN WOUND HEALING and inflammation diminution, Morphometrically and Histopathologically, after topical application of dried extract of ECHINACEA PURPUREA aerial part in RATs, compared with zinc oxide.Methods: Sixty wistar RATs received four full thickness excisional wounds with the aim of surgical punch on the back skin under surgical anesthesia. All RATs were randomly divided into groups 1, 2 and 3, of ECHINACEA PURPUREA, zinc oxide and control, respectively. All of them were treated topically once a day for 21 uninterrupted days. HEALING of the wounds was daily measured by taking digital photographs and analysis. Histopathologic assessment was carried out in the 0th, 3rd, 7th, 14th, and 21st days of treatment period as well, and wound HEALING was assessed using 1 to 6 HEALING grades. Results: According to Morphometric findings, the wound contraction RATe in group 1 after 21 days of skin punching, with wound size of 0.18±0.03 mm2 in contrast with group 2, 2.81±0.21mm2, was much higher than that in other groups. Group 1 with wound contraction RATe of 2.5 times in the day 7 and 3 times in the day 14 more than group 2, had the best wound contraction (p<0.01). histopathologic assessment revealed that, overall HEALING RATe in the group 1 was highest (p<0.01). Conclusion: ECHINACEA PURPUREA dried HERBAL EXTRACT could be a new capable remedy to accelerate SKIN WOUND HEALING because of its potential anti-phlogosis and wound HEALING stimulatory properties.

Cites

HISTOMETRIC AND HISTOPATHOLOGICAL EVALUATION OF THE EFFECT OF SERTRALINE FOLLOWING CUTANEOUS SURGICAL TRAUMA IN THE RAT

References

EFFECTS OF ECHINACEA PURPUREA HERBAL EXTRACT VERSUS ZINC OXIDE IN RAT SKIN WOUND HEALING MODEL, HISTOMETRIC AND HISTOPATHOLOGIC STUDY

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APA: Copy

TAGHIZADEH JAHED, M., JAR ALMASJED, S.H., MOHAMMADNEZHAD, SAMAD, REZAEI, ALI, & DELAZAR, A.. (2008). THE EFFECT OF ECHINACEA PURPUREA AERIAL ORGAN DRIED EXTRACT VS. ZINC OXIDE ON SKIN WOUND HEALING IN RAT: A MORPHOMETRIC & HISTOPATHOLOGIC STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(9), 625-632. SID. https://sid.ir/paper/39175/en

Vancouver: Copy

TAGHIZADEH JAHED M., JAR ALMASJED S.H., MOHAMMADNEZHAD SAMAD, REZAEI ALI, DELAZAR A.. THE EFFECT OF ECHINACEA PURPUREA AERIAL ORGAN DRIED EXTRACT VS. ZINC OXIDE ON SKIN WOUND HEALING IN RAT: A MORPHOMETRIC & HISTOPATHOLOGIC STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(9):625-632. Available from: https://sid.ir/paper/39175/en

IEEE: Copy

M. TAGHIZADEH JAHED, S.H. JAR ALMASJED, SAMAD MOHAMMADNEZHAD, ALI REZAEI, and A. DELAZAR, “THE EFFECT OF ECHINACEA PURPUREA AERIAL ORGAN DRIED EXTRACT VS. ZINC OXIDE ON SKIN WOUND HEALING IN RAT: A MORPHOMETRIC & HISTOPATHOLOGIC STUDY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 9, pp. 625–632, 2008, [Online]. Available: https://sid.ir/paper/39175/en

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