ANTISERUM PRODUCTION IN IMMUNIZED CAMEL BY THE VENOM OF HEMISCORPIUS LEPTURUS SCORPION: EVALUATION OF NEUTRALIZING TEST IN VIVO

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BEHDANI MAHDI; HOSSEININEJAD CHAFI MOHAMMAD; ZEINALI SIROUS; KARIMIPOUR MORTEZA; KHANAHMAD SHAHREZA HOSSEIN; GHASEMI POORIA; ASADZADEH NADER; GHAMNAK ATIEH; POOSHANG BAGHERI KAMRAN; AHARI HAMED; SHAHBAZZADEH DELAVAR

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2010 | Volume:68 | Issue:5 Page(s): 268-273

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Title

ANTISERUM PRODUCTION IN IMMUNIZED CAMEL BY THE VENOM OF HEMISCORPIUS LEPTURUS SCORPION: EVALUATION OF NEUTRALIZING TEST IN VIVO

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Keywords

ANTISERUMQ3

CAMELQ2

SCORPION VENOMQ3

HEMISCORPIUS LEPTURUSQ3

Abstract

Background: Scorpion envenomation is considered as one of the Public Health problems in some countries in the world including Iran. Annually, approximately 30, 000scorpion stings happen in Iran from which 12% belongs to HEMISCORPIUS LEPTURUS (special small closely spaced, bead-shaped jointed tail, similar in the shape to a cows tail, and is locally called ‘‘gaodim’’ (Gao, cow; dim, tail)) with95% mortality. The main treatment is ANTISERUM therapy which is produced in horse and is the only way to neutralize the venom. Due to the anaphylactic shock of the horse ANTISERUM in some of the stung patients other source of ANTISERUM is recommended. In this study the ability of produced CAMEL ANTISERUM in neutralizing the SCORPION VENOM of HEMISCORPIUS LEPTURUSwas performed in Balb/c model.Methods: CAMEL is an animal model that genetically is compatible with human genome utilized in this research to produce ANTISERUM against SCORPION VENOM. Two CAMELs were used for immunization with the venom of HEMISCORPIUS LEPTURUS. ELISA method was used to confirm the immunity. ANTISERUM was produced and used for neutralizing test. The precipitated ANTISERUM with saturated ammonium sulfate (SAS) was also used to perform the neutralizing test in mice.Results: The results indicated that the amount of 200 ml of ANTISERUM and 400 ml of SAS ANTISERUM were able to neutralize the amount of1 LD100 of the venom and the survived the mice from death.Conclusion: The result indicated that CAMEL ANTISERUM against SCORPION VENOM is capable to neutralize the crude venom in mice model. Due to the safety of CAMEL serum in human, it is suggested that the produced ANTISERUM in CAMEL can be substitute with the traditional horse ANTISERUM in scorpion stung patients.

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APA: Copy

BEHDANI, MAHDI, HOSSEININEJAD CHAFI, MOHAMMAD, ZEINALI, SIROUS, KARIMIPOUR, MORTEZA, KHANAHMAD SHAHREZA, HOSSEIN, GHASEMI, POORIA, ASADZADEH, NADER, GHAMNAK, ATIEH, POOSHANG BAGHERI, KAMRAN, AHARI, HAMED, & SHAHBAZZADEH, DELAVAR. (2010). ANTISERUM PRODUCTION IN IMMUNIZED CAMEL BY THE VENOM OF HEMISCORPIUS LEPTURUS SCORPION: EVALUATION OF NEUTRALIZING TEST IN VIVO. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(5), 268-273. SID. https://sid.ir/paper/39304/en

Vancouver: Copy

BEHDANI MAHDI, HOSSEININEJAD CHAFI MOHAMMAD, ZEINALI SIROUS, KARIMIPOUR MORTEZA, KHANAHMAD SHAHREZA HOSSEIN, GHASEMI POORIA, ASADZADEH NADER, GHAMNAK ATIEH, POOSHANG BAGHERI KAMRAN, AHARI HAMED, SHAHBAZZADEH DELAVAR. ANTISERUM PRODUCTION IN IMMUNIZED CAMEL BY THE VENOM OF HEMISCORPIUS LEPTURUS SCORPION: EVALUATION OF NEUTRALIZING TEST IN VIVO. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(5):268-273. Available from: https://sid.ir/paper/39304/en

IEEE: Copy

MAHDI BEHDANI, MOHAMMAD HOSSEININEJAD CHAFI, SIROUS ZEINALI, MORTEZA KARIMIPOUR, HOSSEIN KHANAHMAD SHAHREZA, POORIA GHASEMI, NADER ASADZADEH, ATIEH GHAMNAK, KAMRAN POOSHANG BAGHERI, HAMED AHARI, and DELAVAR SHAHBAZZADEH, “ANTISERUM PRODUCTION IN IMMUNIZED CAMEL BY THE VENOM OF HEMISCORPIUS LEPTURUS SCORPION: EVALUATION OF NEUTRALIZING TEST IN VIVO,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 5, pp. 268–273, 2010, [Online]. Available: https://sid.ir/paper/39304/en

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