Evaluation of Her-2 expression Level in Colorectal Carcinoma in Patients Undergoing Colectomy in Imam Khomeini Hospital of Ahvaz

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Amoozesh Reza; Kheradmand Parvin

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2020 | Volume:19 | Issue:1 Page(s): 27-36

Download Full-Text

Persian Verion

View:

408

Download:

Cites:

Information Journal Paper

Title

Evaluation of Her-2 expression Level in Colorectal Carcinoma in Patients Undergoing Colectomy in Imam Khomeini Hospital of Ahvaz

Author(s)

Amoozesh Reza | Kheradmand Parvin | Issue Writer Certificate

Keywords

Colorectal CancerQ1

Her-2Q1

Tumor GradeQ1

Tumor StageQ2

MetastasisQ2

Abstract

Background and Objective: The aim of this study was to evaluate the level of expression of Her2 protein in patients with colorectal carcinoma in order to better understand the pathophysiology and behavior of inflammatory factors in this disease. Subjects and Methods: In this cross-sectional descriptive study, tissue paraffin blocks of patients referring to Imam Khomeini teaching hospital with pathological diagnosis of Colorectal Cancer were evaluated. Clinical and demographic data of patients were extracted from hospital records. Anti Her-2 monoclonal antibody was used for immunohistochemical staining. Results: In this study, 31 patients with Colorectal Cancer (mean age 65. 1 (range 33 to 89)) were evaluated. Most tumors had grade G2 (54. 8%). Tumor Stage pt3 was also seen in more than half of cases. Lymph node involvement was observed in 29% of cases. The mean staining area was 34. 6% (range 2 to 78%). Her2 staining area in was 30. 65% (range 2 to 85%). More than a quarter of patients were negative and only 6. 5% had a strong positive reaction. Immunohistochemical expression of Her2 marker was not significantly correlated with other pathological characteristics of colorectal tumor including disease grade, stage of disease and Metastasis to lymph nodes. Conclusion: Overall, the findings of this study indicate that more than 70% of colorectal patients show Her2 expression. However, our findings showed no association between Her2 marker and other tumor pathologic variables.

Cites

No record.

References

Cite

APA: Copy

Amoozesh, Reza, & Kheradmand, Parvin. (2020). Evaluation of Her-2 expression Level in Colorectal Carcinoma in Patients Undergoing Colectomy in Imam Khomeini Hospital of Ahvaz. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 19(1 ), 27-36. SID. https://sid.ir/paper/393218/en

Vancouver: Copy

Amoozesh Reza, Kheradmand Parvin. Evaluation of Her-2 expression Level in Colorectal Carcinoma in Patients Undergoing Colectomy in Imam Khomeini Hospital of Ahvaz. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2020;19(1 ):27-36. Available from: https://sid.ir/paper/393218/en

IEEE: Copy

Reza Amoozesh, and Parvin Kheradmand, “Evaluation of Her-2 expression Level in Colorectal Carcinoma in Patients Undergoing Colectomy in Imam Khomeini Hospital of Ahvaz,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 19, no. 1 , pp. 27–36, 2020, [Online]. Available: https://sid.ir/paper/393218/en

Related Journal Papers