THE EVALUATION OF 25-HYDROXY VITAMIN D, CALCIUM, PHOSPHATE AND ALKALINE PHOSPHATASE LEVELS IN EPILEPTIC CHILDREN UNDER ANTIEPILEPTIC MEDICATION

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KEYHANI DOOST ZARRIN; MOAYYERI HESHMAT; KHOSROSHAHI NAHIDEH; MOLATEFI RASOOL

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2011 | Volume:68 | Issue:10 Page(s): 590-593

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Title

THE EVALUATION OF 25-HYDROXY VITAMIN D, CALCIUM, PHOSPHATE AND ALKALINE PHOSPHATASE LEVELS IN EPILEPTIC CHILDREN UNDER ANTIEPILEPTIC MEDICATION

Author(s)

KEYHANI DOOST ZARRIN | MOAYYERI HESHMAT | KHOSROSHAHI NAHIDEH | MOLATEFI RASOOL | Issue Writer Certificate

Keywords

VITAMIN-DQ2

ANTI-EPILEPTIC DRUGSQ3

BONEQ3

METABOLISMQ3

EPILEPTICQ3

CHILDRENQ3

Abstract

Background: Epilepsy is a common disease in the pediatric neurology. There are frequent EPILEPTIC DRUGS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> ANTI-EPILEPTIC DRUGS which are used in management of epilepsy. EPILEPTIC DRUGS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> ANTI-EPILEPTIC DRUGS may have some complications on BONE and VITAMIN-D METABOLISM. In this study we aimed to evaluate VITAMIN-D METABOLISM in EPILEPTIC CHILDREN.Methods: The study was a prospective and cross sectional one. A total 89 EPILEPTIC CHILDREN who were taking EPILEPTIC DRUGS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> ANTI-EPILEPTIC DRUGS for longer than six months with no underlying disorder in Imam Khomeini and Bahrami Hospitals in Tehran, Iran were enrolled in our studyResults: Forty nine boys and 40 girls were enrolled in this study; mean age of the patients was 7.8±2.1 years. Mean duration of anti-epileptic drug therapy was 2.3 years (SD=0.4), 70 of patients were under monotherapy and 19 were under polytherapy. None of the patients had signs of rickets. Serum calcium and phosphor levels were within normal ranges. Serum alkaline phosphates levels were increased more than two times in 43%. 42% had VITAMIN-D deficiency (25-OH Vit D<10 ng/ml) and another 33% had VITAMIN-D insufficiency (10<25-oh Vit D<20 ng/ml). 29 patients (32%) were taking prophylactic supplemental Vit D (200-400 IU/day). There was significant difference between patients taking supplemental VITAMIN-D as prophylaxis and patients who did not (p=0.04). There was no significant difference in VITAMIN-D levels between patients according to age, gender or different drugs.Conclusion: Periodic measurement of 25-hydroxy VITAMIN-D is recommended in EPILEPTIC CHILDREN taking anti-epileptic dugs. Supplemental VITAMIN-D administration in such patients may be helpful.

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APA: Copy

KEYHANI DOOST, ZARRIN, MOAYYERI, HESHMAT, KHOSROSHAHI, NAHIDEH, & MOLATEFI, RASOOL. (2011). THE EVALUATION OF 25-HYDROXY VITAMIN D, CALCIUM, PHOSPHATE AND ALKALINE PHOSPHATASE LEVELS IN EPILEPTIC CHILDREN UNDER ANTIEPILEPTIC MEDICATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(10), 590-593. SID. https://sid.ir/paper/39440/en

Vancouver: Copy

KEYHANI DOOST ZARRIN, MOAYYERI HESHMAT, KHOSROSHAHI NAHIDEH, MOLATEFI RASOOL. THE EVALUATION OF 25-HYDROXY VITAMIN D, CALCIUM, PHOSPHATE AND ALKALINE PHOSPHATASE LEVELS IN EPILEPTIC CHILDREN UNDER ANTIEPILEPTIC MEDICATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;68(10):590-593. Available from: https://sid.ir/paper/39440/en

IEEE: Copy

ZARRIN KEYHANI DOOST, HESHMAT MOAYYERI, NAHIDEH KHOSROSHAHI, and RASOOL MOLATEFI, “THE EVALUATION OF 25-HYDROXY VITAMIN D, CALCIUM, PHOSPHATE AND ALKALINE PHOSPHATASE LEVELS IN EPILEPTIC CHILDREN UNDER ANTIEPILEPTIC MEDICATION,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 10, pp. 590–593, 2011, [Online]. Available: https://sid.ir/paper/39440/en

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