EFFECT OF SPELENECTOMY ON NEED OF TRANSFUSION IN β-THALASSEMIC PATIENTS

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MIRBEHBAHANI N.B.; BEHNAMPOUR N.; AKHAVAN MAHDAVI A.

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Journal: Jundishapur Scientific Medical Journal Year:2009 | Volume:7 | Issue:4 (59) Page(s): 445-450

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Title

EFFECT OF SPELENECTOMY ON NEED OF TRANSFUSION IN β-THALASSEMIC PATIENTS

Author(s)

MIRBEHBAHANI N.B. | BEHNAMPOUR N. | AKHAVAN MAHDAVI A. | Issue Writer Certificate

Keywords

SPLENECTOMYQ3

THALASSEMIAQ3

TRANSFUSIONQ3

Abstract

Objective: THALASSEMIA, a one group of hereditary anemia, is created by mutation of hemoglobin genomes. Management is possible with regular TRANSFUSION with pre-transfusion hemoglobin remaining within 9-10.5g/dl range. In specific cases SPLENECTOMY helps hemoglobin to remain within this range. The aim of this study was to assess the effect of SPLENECTOMY on the need for TRANSFUSION as well as on other important hematological indexes among these patients.Subjects and Methods: In this study 25 major and intermediate splenectomized THALASSEMIA patients (21 major and 4 intermediate) were studied. The need for and the interval between TRANSFUSION one year before and 4 years after SPLENECTOMY were assessed. Analysis of data was made by use of spss 11.5 and t test.Results: TRANSFUSION of packed red blood cells was reduced from 246.12±77.06 ml/kg/year before SPLENECTOMY to 132±96.53 ml/kg/year after SPLENECTOMY (P>0.0001). Mean hemoglobin level was 5.6±0.16 g/dl before splenctomy which was raised to 10.4±0.87 g/dl after SPLENECTOMY. The mean of TRANSFUSION rate was reduced from 18.1 times/year before SPLENECTOMY to 12.86 times/year. Complication observed in two cases. Conclusion: This study establishes a definite place for SPLENECTOMY in both intermediate and major b-thalassemia.

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APA: Copy

MIRBEHBAHANI, N.B., BEHNAMPOUR, N., & AKHAVAN MAHDAVI, A.. (2009). EFFECT OF SPELENECTOMY ON NEED OF TRANSFUSION IN β-THALASSEMIC PATIENTS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 7(4 (59)), 445-450. SID. https://sid.ir/paper/394685/en

Vancouver: Copy

MIRBEHBAHANI N.B., BEHNAMPOUR N., AKHAVAN MAHDAVI A.. EFFECT OF SPELENECTOMY ON NEED OF TRANSFUSION IN β-THALASSEMIC PATIENTS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2009;7(4 (59)):445-450. Available from: https://sid.ir/paper/394685/en

IEEE: Copy

N.B. MIRBEHBAHANI, N. BEHNAMPOUR, and A. AKHAVAN MAHDAVI, “EFFECT OF SPELENECTOMY ON NEED OF TRANSFUSION IN β-THALASSEMIC PATIENTS,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 7, no. 4 (59), pp. 445–450, 2009, [Online]. Available: https://sid.ir/paper/394685/en

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