ASSOCIATION OF GLUTATHIONE S-TRANSFERASE P1 GENE POLYMORPHISM AND UTERINE LEIOMYOMA IN IRANIAN POPULATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOSTAFAVI DEHRAISI SALVA SADAT; SADAT SEYED MEHDI; DAVARI TANHA FATEMEH; AGHASADEGHI MOHAMMAD REZA; SAFARPOUR MAHDI; ABBASI RANJBAR PARINAZ; EBRAHIMI AHMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2014 | Volume:72 | Issue:8 Page(s): 508-514

Download Full-Text

Persian Verion

View:

651

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION OF GLUTATHIONE S-TRANSFERASE P1 GENE POLYMORPHISM AND UTERINE LEIOMYOMA IN IRANIAN POPULATION

Author(s)

Keywords

GSTP1Q2

ILE105VAL POLYMORPHISMQ2

IRANQ2

UTERINE LEIOMYOMAQ2

Abstract

Background: UTERINE LEIOMYOMA is one of the most common benign smooth muscle tumors occurring in 20-40% of women worldwide in their reproductive years. Recent studies revealed that estrogen plays an important role in the pathogenesis of UTERINE LEIOMYOMA. Since, Glutathione s-transferase (GST) gene families are involved in the biosynthesis of estrogen, the prior probability that variants at this locus are associated with UTERINE LEIOMYOMA is likely to be above the null. Therefore, this study was carried out to examine whether GSTP1 ILE105VAL POLYMORPHISM is associated with increased risk of UTERINE LEIOMYOMA in IRANian population.Methods: In this case-control study, 50 women diagnosed with UTERINE LEIOMYOMA and 50 healthy controls were recruited from subjects referred to the Pasteur Institute of IRAN from November 2012 to September 2013. The genomic DNA was extracted from peripheral blood leucocytes using the standard phenol-chloroform method and subsequently the GSTP1 polymorphism was genotyped using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Logistic regression analysis was applied to estimate odds ratios and 95% confidence intervals after age adjustment using the SPSS statistical software package, version 18.0.Results: The results showed significant differences between case and control groups in terms of genotype frequency (P<0.0001). In addition, the results indicated that the presence of the valine allele significantly increased risk of UTERINE LEIOMYOMA about three times more in individuals carrying the mutant allele compared to control group (Odds Ratio: 3.34; 95%CI: 1.82-6.15; P<0.0001).Conclusion: To our knowledge, this is the first study performed in IRANian population assessing the association between GSTP1 ILE105VAL POLYMORPHISM and risk of UTERINE LEIOMYOMA. However, further extensive researches with a large number of samples from different populations and ethnicities are required to validate the results obtained in this study.

Cites

No record.

References

No record.

Cite

APA: Copy

MOSTAFAVI DEHRAISI, SALVA SADAT, SADAT, SEYED MEHDI, DAVARI TANHA, FATEMEH, AGHASADEGHI, MOHAMMAD REZA, SAFARPOUR, MAHDI, ABBASI RANJBAR, PARINAZ, & EBRAHIMI, AHMAD. (2014). ASSOCIATION OF GLUTATHIONE S-TRANSFERASE P1 GENE POLYMORPHISM AND UTERINE LEIOMYOMA IN IRANIAN POPULATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 72(8), 508-514. SID. https://sid.ir/paper/39472/en

Vancouver: Copy

MOSTAFAVI DEHRAISI SALVA SADAT, SADAT SEYED MEHDI, DAVARI TANHA FATEMEH, AGHASADEGHI MOHAMMAD REZA, SAFARPOUR MAHDI, ABBASI RANJBAR PARINAZ, EBRAHIMI AHMAD. ASSOCIATION OF GLUTATHIONE S-TRANSFERASE P1 GENE POLYMORPHISM AND UTERINE LEIOMYOMA IN IRANIAN POPULATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2014;72(8):508-514. Available from: https://sid.ir/paper/39472/en

IEEE: Copy

SALVA SADAT MOSTAFAVI DEHRAISI, SEYED MEHDI SADAT, FATEMEH DAVARI TANHA, MOHAMMAD REZA AGHASADEGHI, MAHDI SAFARPOUR, PARINAZ ABBASI RANJBAR, and AHMAD EBRAHIMI, “ASSOCIATION OF GLUTATHIONE S-TRANSFERASE P1 GENE POLYMORPHISM AND UTERINE LEIOMYOMA IN IRANIAN POPULATION,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 72, no. 8, pp. 508–514, 2014, [Online]. Available: https://sid.ir/paper/39472/en

Related Journal Papers