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Information Journal Paper

Title

Investigation of anti-inflammatory and analgesic effects of hydroalcoholic extract of Scrophularia striata seeds in male mice

Pages

  34-40

Abstract

 Background and aims: In traditional medicine, some plants can relieve pain. Scrophularia striata is traditionally used among people living in Zagros area for its analgesic effects. In this study, anti-inflammatory and analgesic effects of hydroalcoholic extract of Scrophularia striata seeds are investigated. Methods: Eighty-four adult male NMRI Mice were used. Xylene-induced ear edema test was used to evaluate antiinflammatory activity and formalin test was used to evaluate anti-nociceptive activity. In each of these two tests, the animals were divided into 6 groups (n = 7) including control, positive control (receiving dexamethasone in inflammatory test, and morphine in formalin test), and experimental groups receiving hydroalcoholic extract of Scrophularia striata seeds at doses of 30, 60, 90, and 120 mg/kg. Injections were performed intraperitoneally. Results: The results showed that the extract significantly (p < 0. 05) reduced Inflammation at doses of 30, 90 and 120 mg/kg. Furthermore, the extract decreased acute phase of the pain by the dose of 120 mg/kg (p < 0. 05), the peripheral phase by the doses of 60 (p < 0. 05), 90 (p < 0. 001), and 120 (p < 0. 001) mg/kg, and the chronic phase by the doses of 90 (p < 0. 001) and 120 (p < 0. 001) mg/kg. Conclusion: This study showed that hydroalcoholic extract of Scrophularia striata seed has anti-inflammatory and Antinociceptive effects in the animal model.

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    APA: Copy

    Ebrahimi, Ayub, PARANDIN, RAHMATOLLAH, YOUSOFVAND, NAMDAR, & ZARE, SAMAD. (2019). Investigation of anti-inflammatory and analgesic effects of hydroalcoholic extract of Scrophularia striata seeds in male mice. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 3(1 (9) ), 34-40. SID. https://sid.ir/paper/394790/en

    Vancouver: Copy

    Ebrahimi Ayub, PARANDIN RAHMATOLLAH, YOUSOFVAND NAMDAR, ZARE SAMAD. Investigation of anti-inflammatory and analgesic effects of hydroalcoholic extract of Scrophularia striata seeds in male mice. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;3(1 (9) ):34-40. Available from: https://sid.ir/paper/394790/en

    IEEE: Copy

    Ayub Ebrahimi, RAHMATOLLAH PARANDIN, NAMDAR YOUSOFVAND, and SAMAD ZARE, “Investigation of anti-inflammatory and analgesic effects of hydroalcoholic extract of Scrophularia striata seeds in male mice,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 3, no. 1 (9) , pp. 34–40, 2019, [Online]. Available: https://sid.ir/paper/394790/en

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