HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM (L.) GAERTN. AND GLYCYRRHIZA GLABRA L. IN THE RATS

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ASGARI SEDIGHEH; MADANI H.; NADERI GH.; TOORI SH.; TALEB AL HOSEINI M.

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Journal: Journal of Medicinal Plants Year:2005 | Volume:4 | Issue:Supplement Page(s): 0-0

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Title

HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM (L.) GAERTN. AND GLYCYRRHIZA GLABRA L. IN THE RATS

Author(s)

Keywords

HEPATOPROTECTIVEQ4

THIOACTEMIDEQ4

SILYBUMQ3

GLYCYRRIHIZAQ3

Abstract

Bachground: One of the major role of liver is metabolism of xenobiotics and detoxification. But sometimes, during metabolism of xenobiotics produce active and more toxic agents which cause liver damege and disease. Use of nature products from vegetables in the treatment of diseases and liver diseases has a long history, especially in Eastern medicine. Materials and Methods: In this study, we have investigate the protective effects of polyphenolic extracts of SILYBUM marianum and Cichorium intybus. Liver damage induced with hepatotoxin, thioacethamide. Extracts was injected every day for a duration of 3 days, to rats, at a dosis of 25 mg/kg body weight together with thioacetamide at a dosis of 50 mg/kg body weight. In order to investigation the HEPATOPROTECTIVE effect of extracts against thioacetamide, activities of serum aminotrasferases (SGOT and SGPT), alkalin phosphatase, bilirubin, Na+ and K+ were measured. Results: Activities of serum aminotrasferases (SGOT and SGPT), alkalin phosphatase and bilirubin were decreased significantly in rats treatmented with extracts in compared to thioacetamide group. Conclusion: The results showed potent protective effects of these extracts against the thioacetamide induced hepatotoxicity that are due to antioxidant effet of polyphenolic compound.

Cites

EFFECT OF LICORICE (GLYCYRRHIZA GLABRA L.) EXTRACT ON CELL COUNT AND BLOOD PARAMETERS IN MALE MICE

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APA: Copy

ASGARI, SEDIGHEH, MADANI, H., NADERI, GH., TOORI, SH., & TALEB AL HOSEINI, M.. (2005). HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM (L.) GAERTN. AND GLYCYRRHIZA GLABRA L. IN THE RATS. JOURNAL OF MEDICINAL PLANTS, 4(Supplement), 0-0. SID. https://sid.ir/paper/395085/en

Vancouver: Copy

ASGARI SEDIGHEH, MADANI H., NADERI GH., TOORI SH., TALEB AL HOSEINI M.. HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM (L.) GAERTN. AND GLYCYRRHIZA GLABRA L. IN THE RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2005;4(Supplement):0-0. Available from: https://sid.ir/paper/395085/en

IEEE: Copy

SEDIGHEH ASGARI, H. MADANI, GH. NADERI, SH. TOORI, and M. TALEB AL HOSEINI, “HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM (L.) GAERTN. AND GLYCYRRHIZA GLABRA L. IN THE RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 4, no. Supplement, pp. 0–0, 2005, [Online]. Available: https://sid.ir/paper/395085/en

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