The Evaluation of rs11614913 Polymorphism in MIR196A2 Gene and the Risk of Prostate Cancer in Chaharmahal and Bakhtiari Province, Iran

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Vaheb Manijeh; EMADI BAYGI MODJTABA; Injinari Nastaran; TEIMORI HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2019 | Volume:37 | Issue:527 Page(s): 535-541

Download Full-Text

Persian Verion

View:

400

Download:

Cites:

Information Journal Paper

Title

The Evaluation of rs11614913 Polymorphism in MIR196A2 Gene and the Risk of Prostate Cancer in Chaharmahal and Bakhtiari Province, Iran

Author(s)

Vaheb Manijeh | EMADI BAYGI MODJTABA | Injinari Nastaran | TEIMORI HOSSEIN | Issue Writer Certificate

Keywords

GenesQ1

Prostate cancerQ2

MicroRNAsQ1

Genetic polymorphismQ1

Abstract

Background: Genetic variants affect the expression of MicroRNAs (miRNA) resulted in changes in the expression levels of the miRNA target Genes that may lead to the increased risk of cancer. The aim of the current study was to investigate the association between the common single-nucleotide gene polymorphism T < C (rs11614913) in MIR196A2 and the risk of developing Prostate cancer (PCa) in Chahar Mahal and Bakhtiari Province, Iran. Methods: In this case-control study, 99 patients were enrolled in the case group and 100 healthy controls in the control group. From all participants, 5 ml venous blood sample was collected and DNA was extracted by phenol-chloroform extraction. Specific primers were designed for rs11614913 polymorphism, and this polymorphism was genotyped using High Resolution Melt (HRM) analysis. Hardy-Weinberg equilibrium for the genotypes was tested by chi-squared test. The association between different genotypes and the risk of Prostate cancer was investigated by logistic regression analysis. Findings: Among 99 patients, 68 had Prostate cancer and 31 had benign prostatic hyperplasia (BPH). Logistic regression analysis showed that those cases with CC genotype had a higher risk of developing Prostate cancer [Odds ratio (OR) = 1. 08] than T (TT+CT) carriers. Allele frequency analysis revealed that the C allele increased the risk of developing Prostate cancer and BPH 1. 3 more than T allele. Conclusion: The C allele in rs11614913 polymorphism increases the risk of Prostate cancer. Because this polymorphism is present in MIR196A2 gene, evaluation of expression of the miRNA gene and its target Genes in patients with Prostate cancer could be valuable.

Cites

No record.

References

No record.

Cite

APA: Copy

Vaheb, Manijeh, EMADI BAYGI, MODJTABA, Injinari, Nastaran, & TEIMORI, HOSSEIN. (2019). The Evaluation of rs11614913 Polymorphism in MIR196A2 Gene and the Risk of Prostate Cancer in Chaharmahal and Bakhtiari Province, Iran. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 37(527 ), 535-541. SID. https://sid.ir/paper/395500/en

Vancouver: Copy

Vaheb Manijeh, EMADI BAYGI MODJTABA, Injinari Nastaran, TEIMORI HOSSEIN. The Evaluation of rs11614913 Polymorphism in MIR196A2 Gene and the Risk of Prostate Cancer in Chaharmahal and Bakhtiari Province, Iran. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2019;37(527 ):535-541. Available from: https://sid.ir/paper/395500/en

IEEE: Copy

Manijeh Vaheb, MODJTABA EMADI BAYGI, Nastaran Injinari, and HOSSEIN TEIMORI, “The Evaluation of rs11614913 Polymorphism in MIR196A2 Gene and the Risk of Prostate Cancer in Chaharmahal and Bakhtiari Province, Iran,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 37, no. 527 , pp. 535–541, 2019, [Online]. Available: https://sid.ir/paper/395500/en

Related Journal Papers