The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST, ALT, ALP) in Wistar Male Rats Toxicated by Boldenone

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Pashayi P.; Abbassi Daloi A.; BARARI A.R.; Mir Javadi S.R.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:9 | Issue:4 Page(s): 1710-1718

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Title

The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST, ALT, ALP) in Wistar Male Rats Toxicated by Boldenone

Author(s)

Pashayi P. | Abbassi Daloi A. | BARARI A.R. | Mir Javadi S.R. | Issue Writer Certificate

Keywords

Aerobic trainingQ1

BoldenoneQ1

L-carnitineQ1

Hepatic enzymesQ2

Wistar ratsQ1

Abstract

Background & Objective: The aim of this study was to investigate the effect of endurance training and Lcarnitine supplementation on gene expression of Hepatic enzymes (AST, ALT, ALP) in Wistar male rats toxicated by Boldenone. Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 weeks (weight 195± 7. 94g) were randomly divided into five groups: control, no-treatment, Boldenone (5mg/kg), L-carnitine and Aerobic training-L-carnitine. The endurance moderate intensity training program (50-55% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Boldenone injection once a week, on an appointed day, and in the hamstring was conducted in depth. After anesthesia, autopsy was performed and the liver was isolated. The Hepatic enzymes gene expression in the samples were measured by Real Time PCR. Data were analyzed by ttest, One-way ANOVA and post hoc Scheffe at the significant level P<0. 05. Results: The results showed that there was a significant difference between the mean expression of liver enzymes (AST, ALT, ALP) in male Wistar rats in different groups (P<0. 001). The changes in liver enzymes gene expression (AST, ALT, ALP) in L-carnitine and Training-L-carnitine groups were significantly lower than the Boldenone group (P<0. 001). Conclusion: According to the findings of this study, supplementation of L-carnitine with regular Aerobic training reduces liver damage induced by anabolic androgenic steroids.

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APA: Copy

Pashayi, P., Abbassi Daloi, A., BARARI, A.R., & Mir Javadi, S.R.. (2020). The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST, ALT, ALP) in Wistar Male Rats Toxicated by Boldenone. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 9(4 ), 1710-1718. SID. https://sid.ir/paper/395655/en

Vancouver: Copy

Pashayi P., Abbassi Daloi A., BARARI A.R., Mir Javadi S.R.. The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST, ALT, ALP) in Wistar Male Rats Toxicated by Boldenone. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;9(4 ):1710-1718. Available from: https://sid.ir/paper/395655/en

IEEE: Copy

P. Pashayi, A. Abbassi Daloi, A.R. BARARI, and S.R. Mir Javadi, “The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST, ALT, ALP) in Wistar Male Rats Toxicated by Boldenone,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 9, no. 4 , pp. 1710–1718, 2020, [Online]. Available: https://sid.ir/paper/395655/en

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