CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Majidian Azadeh; SEYEDMAJIDI MARYAM; ABBASZADEH HAMID; SHARBATDARAN MAJID; JAFARI SINA; GHOLINIA HEMMAT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Caspian Journal of Dental Research Year:2020 | Volume:9 | Issue:2 Page(s): 26-34

Download Full-Text

Persian Verion

View:

407

Download:

118

Cites:

Information Journal Paper

Title

CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction

Author(s)

Keywords

Lichen planusQ2

Lichenoid eruptionQ1

Langerhans cellsQ1

ImmunohistochemistryQ1

Abstract

Introduction: Oral Lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense. The aim of present study was to determine the immunohistochemical expression of LC in Oral Lichenoid reaction (OLR) and OLP compared with normal oral mucosa (NOM). Materials & Methods: In this cross-sectional study, 61 oral mucosal specimens diagnosed histopathologically as OLP (n=31) and OLR (n=30) and 11 NOM were used to study the immunohistochemical expression of CD1a. The CD1a positive LCs in three regions (basal, suprabasal, and connective tissue) were counted in six randomly selected fields. Data were analyzed using the SPSS 24, T-test, ANOVA, LSD, Games-Howell tests. P<. 05 was considered significant. Results: CD1a expression in OLP and OLR was significantly higher compared to NOM (P<0. 001). CD1a expression in OLP was also significantly higher than OLR (P=0. 009). There was a statistically significant difference between the three groups in basal, suprabasal and connective tissue regions (P<0. 001). The mean of CD1a positive cells in the basal, suprabasal and connective tissue regions was significantly higher in the OLP group than OLR and NOM. Also, in comparison between OLR and NOM, the OLR group had significantly more CD1a positive cells (P<0. 05). Conclusion: Increasing the number of CD1a in OLP and OLR compared with the NOM indicates the role of LC in the pathogenesis of these diseases.

Cites

No record.

References

Cite

APA: Copy

Majidian, Azadeh, SEYEDMAJIDI, MARYAM, ABBASZADEH, HAMID, SHARBATDARAN, MAJID, JAFARI, SINA, & GHOLINIA, HEMMAT. (2020). CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction. CASPIAN JOURNAL OF DENTAL RESEARCH, 9(2 ), 26-34. SID. https://sid.ir/paper/395960/en

Vancouver: Copy

Majidian Azadeh, SEYEDMAJIDI MARYAM, ABBASZADEH HAMID, SHARBATDARAN MAJID, JAFARI SINA, GHOLINIA HEMMAT. CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction. CASPIAN JOURNAL OF DENTAL RESEARCH[Internet]. 2020;9(2 ):26-34. Available from: https://sid.ir/paper/395960/en

IEEE: Copy

Azadeh Majidian, MARYAM SEYEDMAJIDI, HAMID ABBASZADEH, MAJID SHARBATDARAN, SINA JAFARI, and HEMMAT GHOLINIA, “CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction,” CASPIAN JOURNAL OF DENTAL RESEARCH, vol. 9, no. 2 , pp. 26–34, 2020, [Online]. Available: https://sid.ir/paper/395960/en

Related Journal Papers