TITRATED ORAL MISOPROSTOL SOLUTION COMPARED WITH OXYTOCIN FOR INDUCTION OF LABOR IN WOMEN WITH UNFAVORABLE CERVIX

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NIROOMANESH SHIRIN; DADASHALIHA MASOUMEH; AKRAMI MINA

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2011 | Volume:69 | Issue:7 Page(s): 413-419

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Title

TITRATED ORAL MISOPROSTOL SOLUTION COMPARED WITH OXYTOCIN FOR INDUCTION OF LABOR IN WOMEN WITH UNFAVORABLE CERVIX

Author(s)

NIROOMANESH SHIRIN | DADASHALIHA MASOUMEH | AKRAMI MINA | Issue Writer Certificate

Keywords

CERVIXQ2

INDUCTIONQ3

LABORQ3

MISOPROSTOLQ3

OXYTOCINQ3

Abstract

Background: Uterine contractions and an appropriate CERVIX are two important factors in LABOR contributing to good pregnancy outcomes. OXYTOCIN and prostaglandins, such as MISOPROSTOL, are used for the INDUCTION of LABOR. MISOPROSTOL is used for cervical ripening and LABOR INDUCTION. The aim of this trial was to compare the efficacy and safety of titrated oral MISOPROSTOL solution with OXYTOCIN for LABOR INDUCTION in pregnant women with an unfavorable CERVIX.Methods: In this randomized double-blind clinical trial, 140 women with a gestational age of 34−42 weeks and an unfavorable CERVIX were recruited. The participants had an indication for LABOR INDUCTION and had been referred to the Women’s Hospital in Tehran, Iran between January 2010 and January 2011. The participants were randomly assigned to receive20 mg/hour titrated oral MISOPROSTOL plus intravenous placebo or 6 mU/min OXYTOCIN plus oral placebo. In case contractions were inadequate, the drug doses were gradually increased. Pharmacological complications, the mean interval from the start of INDUCTION till vaginal delivery and delivery type were monitored and analyzed in both groups.Results: The mean interval from the start of INDUCTION till vaginal delivery in MISOPROSTOL group was shorter than the OXYTOCIN group (11.07±3.42 vs.14.87±3.21 hours, P=0.001). The frequency of pharmacological complications and vaginal or cesarean deliveries were similar between the two groups (P>0.05).Conclusion: Use of titrated oral MISOPROSTOL is a safe and effective method for LABOR INDUCTION in pregnant women with unfavorable CERVIX. MISOPROSTOL is associated with a shorter interval from INDUCTION to vaginal delivery than OXYTOCIN.

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APA: Copy

NIROOMANESH, SHIRIN, DADASHALIHA, MASOUMEH, & AKRAMI, MINA. (2011). TITRATED ORAL MISOPROSTOL SOLUTION COMPARED WITH OXYTOCIN FOR INDUCTION OF LABOR IN WOMEN WITH UNFAVORABLE CERVIX. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(7), 413-419. SID. https://sid.ir/paper/39598/en

Vancouver: Copy

NIROOMANESH SHIRIN, DADASHALIHA MASOUMEH, AKRAMI MINA. TITRATED ORAL MISOPROSTOL SOLUTION COMPARED WITH OXYTOCIN FOR INDUCTION OF LABOR IN WOMEN WITH UNFAVORABLE CERVIX. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(7):413-419. Available from: https://sid.ir/paper/39598/en

IEEE: Copy

SHIRIN NIROOMANESH, MASOUMEH DADASHALIHA, and MINA AKRAMI, “TITRATED ORAL MISOPROSTOL SOLUTION COMPARED WITH OXYTOCIN FOR INDUCTION OF LABOR IN WOMEN WITH UNFAVORABLE CERVIX,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 7, pp. 413–419, 2011, [Online]. Available: https://sid.ir/paper/39598/en

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