EVALUATION OF NUCLEOSTEMIN GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINPOUR FEIZI M.A.; SAED S.; BABAEI E.; MONTAZERI V.; HALIMI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2012 | Volume:19 | Issue:2 Page(s): 113-125

Download Full-Text

Persian Verion

View:

759

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF NUCLEOSTEMIN GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS

Author(s)

Keywords

NUCLEOSTEMINQ2

BREAST NEOPLASMSQ2

REVERSE TRANSCRIPTACE POLIMERAS CHAIN REACTION (RT-PCR)Q3

Abstract

Background & Aims: NUCLEOSTEMIN is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the present study we evaluate the usefulness of NUCLEOSTEMIN as a potential diagnostic and therapeutic molecular marker in breast tumors.Methods: A total of 41 tumoral and 20 non-tumoral adjacent tissues were studied by Semiquantitative Reverse Transciptase-Polymerase Chain Reaction (RT-PCR).2m was used as an internal control. Data were analyzed through SPSS software.Results: According to the obtained results, NUCLEOSTEMIN is a proliferation marker with higher eapression in breast tumors rather than in adjacent normal tissues. NUCLEOSTEMIN expression level was significantly correlated with profilertion potential of breast benign tumors (p<0.05). The expression of NUCLEOSTEMIN was significantly correlated with the advanced stages of breast tumors (p<0.05).Conclusion: NUCLEOSTEMIN expression level may be used in estimating tumor size and as a potential prognostic marker for determinig breast tumors stage and future metastases. Moreover, NUCLEOSTEMIN inhibition can be an effective sterategy in decreasing the proliferation of breast tumor cell lines.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINPOUR FEIZI, M.A., SAED, S., BABAEI, E., MONTAZERI, V., & HALIMI, M.. (2012). EVALUATION OF NUCLEOSTEMIN GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 19(2), 113-125. SID. https://sid.ir/paper/396/en

Vancouver: Copy

HOSSEINPOUR FEIZI M.A., SAED S., BABAEI E., MONTAZERI V., HALIMI M.. EVALUATION OF NUCLEOSTEMIN GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(2):113-125. Available from: https://sid.ir/paper/396/en

IEEE: Copy

M.A. HOSSEINPOUR FEIZI, S. SAED, E. BABAEI, V. MONTAZERI, and M. HALIMI, “EVALUATION OF NUCLEOSTEMIN GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2, pp. 113–125, 2012, [Online]. Available: https://sid.ir/paper/396/en

Related Journal Papers